Nitsan Z, Nir I
Adv Exp Med Biol. 1986;199:199-222. doi: 10.1007/978-1-4757-0022-0_14.
Diets containing raw soybean products (RSD) fed ad libitum caused a reduction in food consumption and growth, pancreatic enlargement, hypersecretion of digestive enzymes, and enlargement of intestinal segments and their contents in rats, chicks and geese. These effects were found to be related to the concentration of trypsin inhibitor (TI) in the diet. Geese were more sensitive than rats and chicks. Calves fed RSD did not respond in pancreatic hypertrophy and hypersecretion of digestive enzymes, but growth was depressed. Meal-feeding also caused enlargement of the pancreas, digestive tract segments and their contents. The effects of feeding RSD and of meal feeding were found to be additive. In ad libitum feeding the animal can regulate food consumption and moderate the effects of antinutritional factors in the diet. Meal or tube-feeding interfered with this defense mechanism and the negative effects of RSD were accentuated and were lethal in non adapted rats and geese. In long-term studies the incidence of pancreatic nodules was correlated to the level of TI in the diet. Feeding RSD potentiated the carcinogenic effect of azaserine and meal feeding enhanced the incidence and size of the pancreatic nodules in rats fed RSD.
随意采食含生大豆制品（RSD）的日粮会导致大鼠、雏鸡和鹅的采食量和生长量减少、胰腺肿大、消化酶分泌过多以及肠道段及其内容物增大。发现这些影响与日粮中胰蛋白酶抑制剂（TI）的浓度有关。鹅比大鼠和雏鸡更敏感。饲喂RSD的犊牛未出现胰腺肥大和消化酶分泌过多的情况，但生长受到抑制。分顿饲喂也会导致胰腺、消化道段及其内容物增大。发现饲喂RSD和分顿饲喂的影响具有累加性。在随意采食时，动物可以调节采食量并减轻日粮中抗营养因子的影响。分顿或管饲会干扰这种防御机制，RSD的负面影响会加剧，并且对未适应的大鼠和鹅具有致死性。在长期研究中，胰腺结节的发生率与日粮中TI的水平相关。饲喂RSD会增强偶氮丝氨酸的致癌作用，分顿饲喂会增加饲喂RSD的大鼠胰腺结节的发生率和大小。
