Nitsan Z, Nir I, Liener I E
Arch Toxicol Suppl. 1983;6:177-81. doi: 10.1007/978-3-642-69083-9_30.
Diets containing raw soya-beans (RSD) when fed ad libitum cause reduction in growth rate and food utilization, enlargement of the pancreas and increase of its enzyme synthesis. A single meal of raw soya-beans with corn (1:9), tube-fed to geese, caused about 90% mortality, while geese, tube-fed with corn alone, did not show any negative response. No mortality occurred when geese were fed a similar diet ad libitum. Two-week old chicks were fed ad libitum or by tube, twice a day, similar amounts of RSD or heated soya-bean diet (HSD). While the chicks tube-fed HSD behaved similarly to those feeding freely, the chicks tube-fed RSD collapsed after one week. The thymus and bursa of fabricii were atrophied in the RSD tube-fed chicks. Diets containing increasing amounts of raw soya-bean meal (0,20%, 42%, and 80%) were fed freely to weanling rats or as one 4 h meal per day. All the rats fed the 4 h meal containing either 42% or 80% raw soya-bean meal died within 3 days; all the others survived. The rats were trained to meal-feeding by gradual reduction of their access to food. The negative effects of the RSD, i.e. reduced food intake and body weight gain, pancreas enlargement, were much more pronounced in the meal-fed rats than in those fed ad libitum. The differences increased by increasing dietary trypsin inhibitor (TI) (raw soya-bean meal).
随意喂食含生大豆的日粮（RSD）会导致生长速率下降和食物利用率降低，胰腺肿大并增加其酶的合成。给鹅管饲一顿由生大豆和玉米（1:9）组成的日粮，会导致约90%的死亡率，而仅给鹅管饲玉米则未显示出任何负面反应。当随意给鹅喂食类似日粮时，未发生死亡情况。给两周龄的雏鸡随意喂食或每天管饲两次等量的RSD或加热大豆日粮（HSD）。虽然管饲HSD的雏鸡表现与自由采食的雏鸡相似，但管饲RSD的雏鸡一周后就萎靡不振。管饲RSD的雏鸡的胸腺和法氏囊萎缩。给断奶大鼠随意喂食或每天作为一顿4小时的餐食喂食含生大豆粉量逐渐增加（0、20%、42%和80%）的日粮。所有喂食含42%或80%生大豆粉的4小时餐食的大鼠在3天内死亡；其他所有大鼠存活。通过逐渐减少大鼠获取食物的机会使其适应定时进食。RSD的负面影响，即食物摄入量减少和体重增加减少、胰腺肿大，在定时进食的大鼠中比在随意喂食的大鼠中更为明显。随着日粮中胰蛋白酶抑制剂（TI）（生大豆粉）含量的增加，差异增大。
