Yen J T, Jensen A H, Simon J
J Nutr. 1977 Jan;107(1):156-65. doi: 10.1093/jn/107.1.156.
Sixty-eight growing gilts with a 12 kg average initial weight were used in seven trials to study the effect of dietary raw soybean (Harosov) and SBTI (Kunitz soybean trypsin inhibitor) on pancreatic and small intestinal trypsin and chymotrypsin activities. A solvent-extracted, heated soybean meal (SBM) was used, cause reduced growth. Both a single-meal and continuous feeding of the raw soybean diet caused a decrease in the pancreatic trypsin and chymotrypsin activities. In contrast, to the rat and the chick, the pancreas of the pigs did not enlarge subsequent to consumption of the raw soybean or SBTI diets. Raw soybean feeding also resulted in an inhibition of the intestinal trypsin and chymotrypsin activities. This inhibiting effect was greater than that of the SBTI, especially the chymotrypsin-inhibiting effect. This suggested that soybean constituents other than the SBTI, such as the Bowman-Birk inhibitor, caused inhibition. In the pig the inhibition of the intestinal proteolysis may be a major cause of reduced growth when raw soybean is fed.
选用68头平均初始体重为12千克的生长小母猪，分7次试验研究日粮中未加工大豆（哈罗索夫）和大豆胰蛋白酶抑制剂（库尼兹大豆胰蛋白酶抑制剂）对胰腺和小肠中胰蛋白酶及胰凝乳蛋白酶活性的影响。使用了一种经溶剂萃取和加热处理的豆粕，其导致生长减缓。单餐或持续饲喂未加工大豆日粮均会使胰腺中胰蛋白酶和胰凝乳蛋白酶的活性降低。与大鼠和雏鸡不同，猪食用未加工大豆或大豆胰蛋白酶抑制剂日粮后，胰腺并未增大。饲喂未加工大豆还会抑制小肠中胰蛋白酶和胰凝乳蛋白酶的活性。这种抑制作用大于大豆胰蛋白酶抑制剂的抑制作用，尤其是对胰凝乳蛋白酶的抑制作用。这表明除大豆胰蛋白酶抑制剂外，大豆的其他成分，如鲍曼-伯克抑制剂，也会产生抑制作用。在猪中，饲喂未加工大豆时，小肠蛋白水解作用受到抑制可能是生长减缓的主要原因。
