左炔诺孕酮宫内缓释系统在妇科疾病中的临床应用。
Clinical applications of levonorgestrel-releasing intrauterine system to gynecologic diseases.
作者信息
Kim Mi-La, Seong Seok Ju
机构信息
Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
出版信息
Obstet Gynecol Sci. 2013 Mar;56(2):67-75. doi: 10.5468/OGS.2013.56.2.67. Epub 2013 Mar 12.
Abstract
The levonorgestrel-releasing intrauterine system (LNG-IUS), originally designed for contraception, has since been applied to various gynecologic diseases. This article summarizes the current status of clinical applications of LNG-IUS to the treatment of gynecologic diseases such as heavy menstrual bleeding, endometriosis, leiomyoma, adenomyosis, endometrial hyperplasia, and early-stage endometrial cancer.
摘要
左炔诺孕酮宫内节育系统（LNG-IUS）最初设计用于避孕，此后已应用于各种妇科疾病。本文总结了LNG-IUS在治疗月经过多、子宫内膜异位症、子宫肌瘤、子宫腺肌病、子宫内膜增生和早期子宫内膜癌等妇科疾病方面的临床应用现状。
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本文引用的文献
1
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N Engl J Med. 2013 Jan 10;368(2):184-5. doi: 10.1056/NEJMe1214191.
2
Levonorgestrel intrauterine system versus medical therapy for menorrhagia.左炔诺孕酮宫内节育系统与药物治疗月经过多的疗效比较。
N Engl J Med. 2013 Jan 10;368(2):128-37. doi: 10.1056/NEJMoa1204724.
3
Management of endometrial precancers.子宫内膜癌前病变的管理。
Obstet Gynecol. 2012 Nov;120(5):1160-75. doi: 10.1097/aog.0b013e31826bb121.
4
Treatment with medroxyprogesterone acetate plus levonorgestrel-releasing intrauterine system for early-stage endometrial cancer in young women: single-arm, prospective multicenter study: Korean gynecologic oncology group study (KGOG2009).醋酸甲羟孕酮联合左炔诺孕酮宫内缓释系统治疗年轻早期子宫内膜癌的单臂前瞻性多中心研究：韩国妇科肿瘤学组研究（KGOG2009）。
Jpn J Clin Oncol. 2012 Dec;42(12):1215-8. doi: 10.1093/jjco/hys171. Epub 2012 Oct 15.
5
Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis.保留生育功能治疗子宫内膜癌和非典型性复杂子宫内膜增生的复发、缓解和活产率：系统评价和荟萃分析。
Am J Obstet Gynecol. 2012 Oct;207(4):266.e1-12. doi: 10.1016/j.ajog.2012.08.011. Epub 2012 Aug 10.
6
Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial.宫内节育系统用于治疗与子宫内膜异位症相关的盆腔疼痛：一项随机对照试验。
Obstet Gynecol. 2012 Mar;119(3):519-26. doi: 10.1097/AOG.0b013e31824264c3.
7
Emerging indications for the levonorgestrel-releasing intrauterine system (LNG-IUS).左炔诺孕酮宫内节育系统（LNG-IUS）的新适应证。
Acta Obstet Gynecol Scand. 2012 Jan;91(1):3-9. doi: 10.1111/j.1600-0412.2011.01303.x. Epub 2011 Nov 9.
8
Efficacy of the levonorgestrel-releasing intrauterine system in uterine leiomyoma.左炔诺孕酮宫内节育系统治疗子宫肌瘤的疗效。
Int J Gynaecol Obstet. 2012 Jan;116(1):35-8. doi: 10.1016/j.ijgo.2011.07.031. Epub 2011 Sep 28.
9
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Int J Gynecol Cancer. 2011 May;21(4):673-7. doi: 10.1111/IGC.0b013e3181fd9a06.
10
Management of endometrial hyperplasia with a levonorgestrel-releasing intrauterine system: single arm, prospective multicenter study: Korean gynecologic oncology group study (KGOG2006).左炔诺孕酮宫内缓释系统治疗子宫内膜增生的管理：单臂、前瞻性多中心研究：韩国妇科肿瘤学组研究（KGOG2006）。
Jpn J Clin Oncol. 2011 Jun;41(6):817-9. doi: 10.1093/jjco/hyr048. Epub 2011 Apr 7.
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