Kim Jin Ju, Choi Young Min, Kang Jin Hwa, Hwang Kyu Ri, Chae Soo Jin, Kim Sun Mie, Ku Seung Yup, Kim Seok Hyun, Kim Jung Gu, Moon Shin Yong
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. ; Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.
Obstet Gynecol Sci. 2013 Jul;56(4):249-55. doi: 10.5468/ogs.2013.56.4.249. Epub 2013 Jul 15.
Metabolic disturbances are well-recognized clinical features of polycystic ovary syndrome (PCOS). Carotid intima-media thickness (CIMT) has been widely used as a surrogate marker of atherosclerosis and cardiovascular disease (CVD). CIMT in women with PCOS has been investigated in many studies, but there has been only one report in the Korean population. The aim of the present study was to compare the presence of subclinical atherosclerosis in young untreated Korean women with PCOS and age-matched controls, specifically by measuring their CIMT.
CIMT was measured by one radiologist in 56 PCOS patients and 56 controls. To compare the CIMT according to PCOS phenotypes, women with PCOS were divided into two subgroups according to the presence of hyperandrogenism.
Although PCOS patients were more obese and had higher blood pressure and insulin resistance index than the age-matched controls, the CIMT was not different between the two groups (0.49 ± 0.09 mm in PCOS patients vs. 0.50 ± 0.11 mm in controls, respectively, p = 0.562). When the CIMT in the control group was compared with hyperandrogenic and non-hyperandrogenic PCOS groups, also no significant differences were found.
Despite the significant differences in some vascular risk factors between women with PCOS and controls, PCOS patients did not have a significantly higher CIMT (even in the hyperandrogenic subgroups). Although our study did not show the increased risk of subclinical atherosclerosis in PCOS patients, the role of CIMT continues to be investigated considering the importance of screening and monitoring CVD risk factors in women with PCOS.
代谢紊乱是多囊卵巢综合征（PCOS）公认的临床特征。颈动脉内膜中层厚度（CIMT）已被广泛用作动脉粥样硬化和心血管疾病（CVD）的替代标志物。许多研究对PCOS女性的CIMT进行了调查，但韩国人群中仅有一篇报道。本研究的目的是比较未经治疗的年轻韩国PCOS女性与年龄匹配的对照组中亚临床动脉粥样硬化的情况，具体方法是测量她们的CIMT。
由一名放射科医生对56例PCOS患者和56例对照者进行CIMT测量。为了根据PCOS表型比较CIMT，将PCOS女性根据高雄激素血症的存在分为两个亚组。
尽管PCOS患者比年龄匹配的对照组更肥胖，血压和胰岛素抵抗指数更高，但两组之间的CIMT没有差异（PCOS患者为0.49±0.09mm，对照组为0.50±0.11mm，p = 0.562）。当将对照组的CIMT与高雄激素血症和非高雄激素血症的PCOS组进行比较时，也未发现显著差异。
尽管PCOS女性与对照组在一些血管危险因素上存在显著差异，但PCOS患者的CIMT并没有显著升高（即使在高雄激素血症亚组中也是如此）。尽管我们的研究未显示PCOS患者亚临床动脉粥样硬化风险增加，但考虑到筛查和监测PCOS女性CVD危险因素的重要性，CIMT的作用仍在继续研究中。
