Garg Neeraj, Dharmalingam Mala, Prabhu Vinay, Murthy N S
Department of Endocrinology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
Department of Radiology, M.S. Ramaiah Medical College, Bengaluru, Karnataka, India.
Indian J Endocrinol Metab. 2016 Sep-Oct;20(5):662-666. doi: 10.4103/2230-8210.190552.
Polycystic ovary syndrome (PCOS) is a common endocrine problem, which is now recognized as not only a reproductive but also a metabolic disorder with long-term effects on women's health, it has a prevalence of 5-10% in India. Among PCOS, it has been reported to have a higher incidence of cardiovascular disorders. Epidemiological studies have demonstrated an association between an increase in the carotid intimo-medial wall thickness (CIMT) and cardiovascular dysfunction. The objective of this study was to compare the CIMT of PCOS with normal women.
The cross-sectional case-control study was conducted in a tertiary care Hospital in South India. Fifty-four subjects with polycystic ovarian disease and 54 healthy women were enrolled into the study. PCOS was diagnosed by Rotterdam criteria, 2003. Both groups of women were investigated with CIMT and cardiovascular dysfunction.
The mean age of women with PCOS and controls were 24.4 ± 5.3 and 27.7 ± 6.0, respectively, whereas body mass index was significantly higher in PCOS than controls group. Mean carotid IMT was significantly higher in PCOS subjects (0.51 ± 0.078) than control subjects (0.44 ± 0.06).
Higher CIMT values were observed in PCOS group compared to control group indicating the importance for measuring CIMT in women with PCOS to predict the risk of cardiovascular dysfunction (CVD).
多囊卵巢综合征（PCOS）是一种常见的内分泌问题，目前不仅被认为是一种生殖系统疾病，也是一种对女性健康有长期影响的代谢紊乱疾病，在印度的患病率为5%-10%。在PCOS患者中，据报道心血管疾病的发病率较高。流行病学研究表明，颈动脉内膜中层厚度（CIMT）增加与心血管功能障碍之间存在关联。本研究的目的是比较PCOS患者与正常女性的CIMT。
在印度南部的一家三级护理医院进行了横断面病例对照研究。54例多囊卵巢疾病患者和54例健康女性纳入研究。PCOS根据2003年鹿特丹标准进行诊断。两组女性均接受了CIMT和心血管功能障碍检查。
PCOS患者和对照组女性的平均年龄分别为24.4±5.3岁和27.7±6.0岁，而PCOS患者的体重指数显著高于对照组。PCOS患者的平均颈动脉内膜中层厚度（0.51±0.078）显著高于对照组（0.44±0.06）。
与对照组相比，PCOS组观察到更高的CIMT值，这表明测量PCOS女性的CIMT对于预测心血管功能障碍（CVD）风险的重要性。
