Kasaian Jamal, Iranshahy Milad, Iranshahi Mehrdad
Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences , Mashhad , Iran.
Pharm Biol. 2013 Dec 13. doi: 10.3109/13880209.2013.846916.
Abstract Context: Galbanic acid (GA) is a biologically active sesquiterpene coumarin from Ferula species (Apiaceae). This compound showed various biological properties including anticancer, cancer chemopreventive, anticoagulant, antiviral, and antileishmanial activities. Objectives: This article is a review on the synthesis, biosynthesis, and biological activities of GA. In addition, we discussed gaps in our knowledge about GA that deserve future research. In this article, we also evaluated the drug-likeness of GA in silico. Methods: All relevant databases were searched for the terms "galbanic acid", "methyl galbanate", "Ferula" and "sesquiterpene coumarin" without limitation, up to May 2013. Information on GA was collected via electronic search using Pubmed, Scopus, Web of Science, and Sciencedirect. All physicochemical parameters used for the prediction of drug-likeness were calculated using MarvinSketch (version 5.11, academic package, ChemAxon). Results: This compound showed various biological properties including anticancer, cancer chemopreventive, anticoagulant, antiviral and antileishmanial activities. GA can inhibit the growth of prostate cancer cells via decreasing androgen receptor abundance. In silico physicochemical studies on GA showed that this compound has drug-like properties, the parameters that are important to predict potential of a compound for being a future drug. Conclusion: GA is a valuable natural product with various biological activities. New discoveries with GA are to be expected.
摘要 背景：没药酸（GA）是一种来自阿魏属植物（伞形科）的具有生物活性的倍半萜香豆素。该化合物具有多种生物学特性，包括抗癌、癌症化学预防、抗凝、抗病毒和抗利什曼原虫活性。目的：本文是关于GA的合成、生物合成及生物学活性的综述。此外，我们讨论了关于GA的知识空白，这些空白值得未来研究。在本文中，我们还通过计算机模拟评估了GA的类药性。方法：截至2013年5月，对所有相关数据库进行不限定检索，检索词为“没药酸”、“没药酸甲酯”、“阿魏属”和“倍半萜香豆素”。通过使用PubMed、Scopus、科学网和科学Direct进行电子检索收集有关GA的信息。用于预测类药性的所有物理化学参数均使用MarvinSketch（版本5.11，学术版，ChemAxon）进行计算。结果：该化合物具有多种生物学特性，包括抗癌、癌症化学预防、抗凝、抗病毒和抗利什曼原虫活性。GA可通过降低雄激素受体丰度来抑制前列腺癌细胞的生长。对GA的计算机模拟物理化学研究表明，该化合物具有类药性质，这些参数对于预测一种化合物成为未来药物的潜力很重要。结论：GA是一种具有多种生物学活性的有价值的天然产物。预计GA会有新的发现。
