Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Türkiye.
Department of Pharmacognosy, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul 34116, Türkiye.
Molecules. 2023 Jul 28;28(15):5733. doi: 10.3390/molecules28155733.
Six new sesquiterpene coumarin ethers, namely turcicanol A (), turcicanol A acetate (), turcicanol B (), turcica ketone (), 11'-dehydrokaratavicinol (), and galbanaldehyde (), and one new sulfur-containing compound, namely turcicasulphide (), along with thirty-two known secondary metabolites were isolated from the root of the endemic species Akalın, Miski, & Tuncay through a bioassay-guided isolation approach. The structures of the new compounds were elucidated by spectroscopic analysis and comparison with the literature. Cell growth inhibition of colon cancer cell lines (COLO205 and HCT116) and kidney cancer cell lines (UO31 and A498) was used to guide isolation. Seventeen of the compounds showed significant activity against the cell lines.
从特有种 Akalın、Miski 和 Tuncay 的根部分离得到六个新的倍半萜香豆素醚类化合物，分别为 turcicanol A()、turcicanol A 乙酸酯()、turcicanol B()、turcica 酮()、11'-去氢卡瓦胡椒醇()和洋甘菊醛()，以及一个新的含硫化合物 turcicasulphide()，以及三十二个已知的次级代谢产物。通过生物测定指导的分离方法从根部分离得到这些化合物。通过光谱分析和与文献比较阐明了新化合物的结构。结肠癌细胞系（COLO205 和 HCT116）和肾癌细胞系（UO31 和 A498）的细胞生长抑制被用于指导分离。其中 17 种化合物对细胞系表现出显著的活性。
