Biological activities of farnesiferol C: a review.

Farnesiferol C (FC) is a sesquiterpene coumarin, with a unique chemical structure, isolated from Ferula (Apiaceae) species including Ferula assa-foetida and Ferula szowitsiana. The compound is an important natural product with different biological activities. Recently, researchers have been interested in FC and begun to investigate its biological effects. They have shown that FC possesses various biological properties including cytotoxic, apoptotic, MDR reversal, antitumor, antimutagenic, and antiviral activity. In addition, FC has shown moderate neuroprotective activity against oxygen-glucose deprivation in vitro. This review summarizes the biological activities of FC that has been published to date. A complete search performed on relevant databases consists of Pubmed, Scopus, Web of science, Google scholar, Science direct, and Magiran. Selected keywords were sesquiterpene coumarin, farnesiferol C, biological activity, cytotoxicity, pharmacology, anticancer, and anti-angiogenesis. All of the data were checked out and irrelevant articles were discarded.