Kasaian Jamal, Mohammadi Ameneh
a Natural Products and Medicinal Plants Research Center , North Khorasan University of Medical Sciences , Bojnurd 9417694735 , Iran.
J Asian Nat Prod Res. 2018 Jan;20(1):27-35. doi: 10.1080/10286020.2017.1379997. Epub 2017 Sep 26.
Farnesiferol C (FC) is a sesquiterpene coumarin, with a unique chemical structure, isolated from Ferula (Apiaceae) species including Ferula assa-foetida and Ferula szowitsiana. The compound is an important natural product with different biological activities. Recently, researchers have been interested in FC and begun to investigate its biological effects. They have shown that FC possesses various biological properties including cytotoxic, apoptotic, MDR reversal, antitumor, antimutagenic, and antiviral activity. In addition, FC has shown moderate neuroprotective activity against oxygen-glucose deprivation in vitro. This review summarizes the biological activities of FC that has been published to date. A complete search performed on relevant databases consists of Pubmed, Scopus, Web of science, Google scholar, Science direct, and Magiran. Selected keywords were sesquiterpene coumarin, farnesiferol C, biological activity, cytotoxicity, pharmacology, anticancer, and anti-angiogenesis. All of the data were checked out and irrelevant articles were discarded.
法尼西佛醇C（FC）是一种倍半萜香豆素，具有独特的化学结构，从阿魏属（伞形科）植物中分离得到，包括阿魏和索氏阿魏。该化合物是一种具有多种生物活性的重要天然产物。最近，研究人员对FC产生了兴趣，并开始研究其生物学效应。他们发现FC具有多种生物学特性，包括细胞毒性、凋亡诱导、多药耐药逆转、抗肿瘤、抗诱变和抗病毒活性。此外，FC在体外对氧糖剥夺显示出适度的神经保护活性。本综述总结了迄今为止已发表的FC的生物学活性。在相关数据库（包括PubMed、Scopus、科学网、谷歌学术、科学Direct和Magiran）上进行了全面检索。选定的关键词为倍半萜香豆素、法尼西佛醇C、生物学活性、细胞毒性、药理学、抗癌和抗血管生成。所有数据均经过核查，无关文章被剔除。
