Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.
Vox Sang. 2014 Jul;107(1):44-9. doi: 10.1111/vox.12123. Epub 2013 Dec 13.
Restless legs syndrome (RLS) is a frequent condition with a prevalence of 5-15% in the general population. Clinical and genetic observations have shown that iron deficiency, highly prevalent among blood donors, can be related to RLS. The objective of this study was to assess the prevalence of RLS in female blood donors 1 week after blood donation.
One week after blood donation, 291 female blood donors, aged <50 years, self-responded to all four RLS questions defined by the 1995 International RLS study group. Blood donation rate, fatigue, aerobic capacity, menstruation, mood disorder and quality of life were also assessed along with haemoglobin and ferritin blood concentrations.
Prevalence of RLS in female blood donors 1 week after blood donation was 6·9% (CI 95% 4·2-10·4%). Female blood donors with RLS had a higher prevalence of hyper-menorrhaea (P = 0·033) and were significantly more tired (P = 0·001). We observed no associations between RLS and number of previous donations (P = 0·409), aerobic capacity (P = 0·476), mood disorder (P = 0·169), quality of life (P = 0·356), haemoglobin (P = 0·087), and serum ferritin level (P = 0·446).
Restless legs syndrome prevalence in female blood donors is not as important as described in some other studies, which could reassure blood donors. The prevalence of hypermenorrhaea and fatigue is higher in RLS blood donors. Therefore, screening for fatigue and hypermenorrhaea could be considered as these symptoms are associated with RLS in female blood donors.
不宁腿综合征（RLS）是一种常见病症，在普通人群中的患病率为 5%-15%。临床和遗传观察表明，缺铁（在献血者中高度普遍）可能与 RLS 有关。本研究的目的是评估女性献血者在献血后 1 周时 RLS 的患病率。
献血后 1 周，291 名年龄<50 岁的女性献血者自行回答了由 1995 年国际 RLS 研究组定义的所有四个 RLS 问题。还评估了献血率、疲劳、有氧能力、月经、情绪障碍和生活质量以及血红蛋白和铁蛋白的血液浓度。
女性献血者在献血后 1 周时 RLS 的患病率为 6.9%（95%CI 4.2-10.4%）。患有 RLS 的女性献血者月经过多的发生率更高（P=0.033），且疲劳感更明显（P=0.001）。我们未观察到 RLS 与既往献血次数（P=0.409）、有氧能力（P=0.476）、情绪障碍（P=0.169）、生活质量（P=0.356）、血红蛋白（P=0.087）和血清铁蛋白水平（P=0.446）之间存在关联。
女性献血者中 RLS 的患病率并不像其他一些研究中描述的那么重要，这可以让献血者安心。RLS 献血者中月经过多和疲劳的发生率更高。因此，筛查疲劳和月经过多可能是必要的，因为这些症状与女性献血者的 RLS 有关。
