Didriksen Maria, Rigas Andreas S, Allen Richard P, Burchell Brendan J, Di Angelantonio Emanuele, Nielsen Maria H, Jennum Poul, Werge Thomas, Erikstrup Christian, Pedersen Ole B, Bruun Mie T, Burgdorf Kristoffer S, Sørensen Erik, Ullum Henrik
Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Department of Neurology, John Hopkins University School of Medicine, Baltimore, MD, USA.
Sleep Med. 2017 Aug;36:55-61. doi: 10.1016/j.sleep.2017.04.014. Epub 2017 May 26.
Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by uncomfortable sensations in the legs. RLS often occurs as a comorbid condition. Besides an increased risk of iron deficiency, blood donors are considered to be generally healthy. Blood donors are therefore an ideal population for studying factors associated with RLS occurrence, herein the role of iron. It is suggested that RLS is linked to sex, age, low socioeconomic status, unhealthy lifestyle, and iron deficiency. The objective of this study is therefore to estimate the RLS prevalence and identify associated biological, sociodemographic, economic, and lifestyle factors in a population of blood donors.
A total of 13,448 blood donors enrolled in the Danish Blood Donor Study from May 2015 to May 2016. RLS cases were identified using the validated Cambridge-Hopkins RLS-questionnaire. Logistic regression models were applied to assess the relationship between RLS and data on socially related factors collected using questionnaires and population registers.
In this study, 7.2% women and 4.5% men were classified with RLS. RLS was associated with: female sex, high age, smoking, frequent alcohol consumption, and low education. RLS-related symptoms were associated with obesity, parity and donation intensity three years prior to inclusion among women. RLS was not related to: reduced plasma ferritin, employment status, and income.
RLS is a frequent disorder in otherwise healthy individuals. The associations discovered in this study can be utilized in preventing or reducing RLS symptoms.
不宁腿综合征（RLS）是一种神经感觉运动障碍，其特征为腿部出现不适感。RLS常作为一种合并症出现。除了缺铁风险增加外，献血者通常被认为健康状况良好。因此，献血者是研究与RLS发生相关因素（此处指铁的作用）的理想人群。有人提出RLS与性别、年龄、社会经济地位低、不健康的生活方式及缺铁有关。因此，本研究的目的是估计献血人群中RLS的患病率，并确定相关的生物学、社会人口统计学、经济和生活方式因素。
共有13448名献血者参与了2015年5月至2016年5月的丹麦献血者研究。使用经过验证的剑桥-霍普金斯RLS问卷来识别RLS病例。应用逻辑回归模型来评估RLS与通过问卷和人口登记册收集的社会相关因素数据之间的关系。
在本研究中，7.2%的女性和4.5%的男性被归类为患有RLS。RLS与以下因素相关：女性性别、高龄、吸烟、频繁饮酒和低教育程度。与RLS相关的症状在女性中与肥胖、生育情况以及纳入研究前三年的献血强度有关。RLS与以下因素无关：血浆铁蛋白降低、就业状况和收入。
RLS在其他方面健康的个体中是一种常见疾病。本研究中发现的关联可用于预防或减轻RLS症状。
