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Gramicidin S analogs with a D-Ala, Gly, or L-Ala residue in place of the D-Phe residue: molecular conformations and interactions with phospholipid membrane.

作者信息

Higashijima T, Miyazawa T, Kawai M, Nagai U

出版信息

Biopolymers. 1986 Dec;25(12):2295-307. doi: 10.1002/bip.360251207.

DOI:10.1002/bip.360251207
PMID:2432956
Abstract
摘要

相似文献

1
Gramicidin S analogs with a D-Ala, Gly, or L-Ala residue in place of the D-Phe residue: molecular conformations and interactions with phospholipid membrane.
Biopolymers. 1986 Dec;25(12):2295-307. doi: 10.1002/bip.360251207.
2
Studies of peptide antibiotics. XLIII. Syntheses of gramicidin S analogs containing D-serine or dehydroalanine in place of D-phenylalanine and asymmetric hydrogenation of the dehydroalanine residue.
Int J Pept Protein Res. 1983 Mar;21(3):313-21.
3
Effects of alanine and glycine substitution for tryptophan on the heterogeneity of gramicidin A analogs in micelles.用丙氨酸和甘氨酸取代色氨酸对短杆菌肽A类似物在胶束中异质性的影响。
J Magn Reson. 1997 Jan;124(1):132-9. doi: 10.1006/jmre.1996.7493.
4
Proline residue-modified polycationic analogs of gramicidin S with high antibacterial activity against both Gram-positive and Gram-negative bacteria and low hemolytic activity.短杆菌肽 S 的脯氨酸残基修饰的聚阳离子类似物，对革兰氏阳性菌和革兰氏阴性菌均具有高抗菌活性且溶血活性低。
J Pept Res. 2005 Jan;65(1):98-104. doi: 10.1111/j.1399-3011.2004.00204.x.
5
Comparison of conformation and antimicrobial activity of synthetic analogs of gramicidin S: Stereochemical consideration of the role of D-phenylalanine in the antibiotic.
Biopolymers. 1978 Jun;17(6):1549-65. doi: 10.1002/bip.1978.360170613.
6
[The effect of side radicals on the peptide structure. Surface of potential energy of model alanine and phenylalanine dipeptides].
Mol Biol (Mosk). 1988 Sep-Oct;22(5):1217-25.
7
Homooligopeptides composed of hydrophobic amino acid residues interact in a specific manner by taking alpha-helix or beta-structure toward lipid bilayers.由疏水氨基酸残基组成的同型寡肽通过对脂质双层采取α-螺旋或β-结构以特定方式相互作用。
Biopolymers. 1995 Sep;36(3):391-8. doi: 10.1002/bip.360360312.
8
Exploiting the right side of the Ramachandran plot: substitution of glycines by D-alanine can significantly increase protein stability.利用拉氏构象图的右侧：用D-丙氨酸取代甘氨酸可显著提高蛋白质稳定性。
J Am Chem Soc. 2004 Oct 20;126(41):13194-5. doi: 10.1021/ja047119i.
9
Immunosuppressive activity of some peptides related to cycloamanide A (CyA A) and to the active fragment of a peptide immunomodulator from ovine colostrum.一些与环鹅膏肽A（CyA A）以及来自羊初乳的一种肽免疫调节剂活性片段相关的肽的免疫抑制活性。
Arch Immunol Ther Exp (Warsz). 1993;41(5-6):297-301.
10
Beta VI turns in peptides and proteins: a model peptide mimicry.βVI 转化肽和蛋白质：一种模拟肽模型。
Proteins. 1993 Mar;15(3):235-51. doi: 10.1002/prot.340150303.

引用本文的文献

1
Sequence inversion and phenylalanine surrogates at the beta-turn enhance the antibiotic activity of gramicidin S.β-转角处的序列倒位和苯丙氨酸替代增强了短杆菌肽 S 的抗菌活性。
J Med Chem. 2010 May 27;53(10):4119-29. doi: 10.1021/jm100143f.
2
Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn.短杆菌肽S的治疗指数在β-转角处受到D-苯丙氨酸类似物的强烈调节。
J Med Chem. 2009 Feb 12;52(3):664-74. doi: 10.1021/jm800886n.
3
Atomic detail peptide-membrane interactions: molecular dynamics simulation of gramicidin S in a DMPC bilayer.
原子尺度的肽-膜相互作用：短杆菌肽S在二肉豆蔻酰磷脂酰胆碱双层膜中的分子动力学模拟
Biophys J. 2000 Oct;79(4):1718-30. doi: 10.1016/S0006-3495(00)76424-1.