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Comparison of conformation and antimicrobial activity of synthetic analogs of gramicidin S: Stereochemical consideration of the role of D-phenylalanine in the antibiotic.

作者信息

Kawai M, Nagai U

出版信息

Biopolymers. 1978 Jun;17(6):1549-65. doi: 10.1002/bip.1978.360170613.

DOI:10.1002/bip.1978.360170613
PMID:77690
Abstract
摘要

相似文献

1
Comparison of conformation and antimicrobial activity of synthetic analogs of gramicidin S: Stereochemical consideration of the role of D-phenylalanine in the antibiotic.
Biopolymers. 1978 Jun;17(6):1549-65. doi: 10.1002/bip.1978.360170613.
2
Structure-activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S.基于短杆菌肽S的从头设计的环状抗菌肽的构效关系
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3
Studies of peptide antibiotics. XLIII. Syntheses of gramicidin S analogs containing D-serine or dehydroalanine in place of D-phenylalanine and asymmetric hydrogenation of the dehydroalanine residue.
Int J Pept Protein Res. 1983 Mar;21(3):313-21.
4
Environment- and sequence-dependent modulation of the double-stranded to single-stranded conformational transition of gramicidin A in membranes.膜中短杆菌肽A从双链到单链构象转变的环境和序列依赖性调控
Biochemistry. 1998 Oct 6;37(40):14279-91. doi: 10.1021/bi980733k.
5
Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.含修饰D-苯丙氨酸残基的不对称短杆菌肽S类似物的合成与生物学评价
Bioorg Med Chem. 2009 Sep 1;17(17):6318-28. doi: 10.1016/j.bmc.2009.07.042. Epub 2009 Jul 25.
6
Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product.含有芳基化糖氨基酸的β-转角修饰短杆菌肽S类似物具有与天然产物相当的抗菌和溶血活性。
J Am Chem Soc. 2006 Jun 14;128(23):7559-65. doi: 10.1021/ja0588510.
7
Gramicidin S analogs with a D-Ala, Gly, or L-Ala residue in place of the D-Phe residue: molecular conformations and interactions with phospholipid membrane.
Biopolymers. 1986 Dec;25(12):2295-307. doi: 10.1002/bip.360251207.
8
Gramicidin S analogs having six basic amino acid residues.具有六个碱性氨基酸残基的短杆菌肽S类似物。
J Antibiot (Tokyo). 2009 Oct;62(10):597-9. doi: 10.1038/ja.2009.81. Epub 2009 Aug 28.
9
Proline residue-modified polycationic analogs of gramicidin S with high antibacterial activity against both Gram-positive and Gram-negative bacteria and low hemolytic activity.短杆菌肽 S 的脯氨酸残基修饰的聚阳离子类似物，对革兰氏阳性菌和革兰氏阴性菌均具有高抗菌活性且溶血活性低。
J Pept Res. 2005 Jan;65(1):98-104. doi: 10.1111/j.1399-3011.2004.00204.x.
10
A novel, antimicrobially active analog of gramicidin S without amphiphilic conformation.一种新型的、无两亲性构象的短杆菌肽S抗菌活性类似物。
J Antibiot (Tokyo). 2006 Jun;59(6):370-2. doi: 10.1038/ja.2006.54.

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Preparation and Use of a General Solid-Phase Intermediate to Biomimetic Scaffolds and Peptide Condensations.通用固相中间体制备及仿生支架和肽缩合的应用。
Molecules. 2018 Jul 18;23(7):1762. doi: 10.3390/molecules23071762.
2
Sequence inversion and phenylalanine surrogates at the beta-turn enhance the antibiotic activity of gramicidin S.β-转角处的序列倒位和苯丙氨酸替代增强了短杆菌肽 S 的抗菌活性。
J Med Chem. 2010 May 27;53(10):4119-29. doi: 10.1021/jm100143f.