Department of Biochemical Sciences, Sapienza University of Roma, p.le Aldo Moro, 5, 00185 Roma, Italy.
Med Chem. 2014 May;10(3):237-45. doi: 10.2174/15734064113096660053.
Resveratrol is a bioactive polyphenol found in many vegetables. It is well known for its multiple pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, anticancer, neuroprotective and cardioprotective effects. In vitro evidence of resveratrol efficacy is widespread, however, many concerns regarding its effectiveness in vivo arise from its poor stability in vitro and bioavailability following oral ingestion. This review focuses on the in vitro stability, with special focus on the photochemical stability of resveratrol, and on the therapeutic perspectives of this molecule due to its low bioavailability.
白藜芦醇是一种存在于许多蔬菜中的生物活性多酚。它以多种药理活性而闻名，如抗炎、抗氧化、抗菌、抗癌、神经保护和心脏保护作用。白藜芦醇在体外的疗效证据广泛存在，然而，由于其在体外稳定性差和口服摄入后的生物利用度低，许多人对其在体内的有效性表示担忧。本综述重点介绍了白藜芦醇的体外稳定性，特别关注其光化学稳定性，并探讨了由于其生物利用度低，该分子的治疗前景。
