Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Diabetes Metab Res Rev. 2017 Sep;33(6). doi: 10.1002/dmrr.2896. Epub 2017 Apr 18.
Secreted frizzled-related protein-5 (Sfrp5) is a novel adipokine, and it has been found to link insulin resistance with diabetes. Animal studies have revealed the role of Sfrp5 in regulating lipid and glucose metabolism. The objective of this study was to investigate the relationship between Sfrp5 and the metabolic syndrome (MetS) in a cross-sectional study.
We conducted a series of cross-sectional studies of Chinese population including 194 control participants and 90 MetS patients. Circulating Sfrp5 concentrations were determined by ELISA. The relationships between circulating Sfrp5 levels and MetS components were assessed.
Circulating Sfrp5 was significantly lower in newly examined MetS patients than in control participants (49.1 ± 17.2 vs 61.6 ± 23.2 μg/L, P < .01). Circulating Sfrp5 correlated negatively with markers of adiposity (waist-to-hip ratio, body mass index, and free fatty acids, P < .001 or P < .05). Furthermore, Sfrp5 levels correlated with fasting insulin, 2 h-ins, fasting blood glucose, 2 h post-glucose load blood glucose, HbA , and homeostasis model assessment of insulin resistance. In addition, circulating Sfrp5 levels were closely associated with blood pressure, high-density lipoprotein cholesterol, triglycerides, and atherosclerotic index. Circulating concentrations of Sfrp5 decreased progressively with continued increases in the numbers of MetS components. The analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating Sfrp5 to predict MetS was 46.8 μg/L (sensitivity 70.1 %, specificity 47.8 %, and AUC 0.66).
We conclude that Sfrp5 may be an adipokine that is associated with the pathogenesis of MetS in humans.
分泌型卷曲相关蛋白 5（Sfrp5）是一种新型脂肪因子，它已被发现与胰岛素抵抗和糖尿病有关。动物研究表明 Sfrp5 在调节脂质和葡萄糖代谢方面发挥作用。本研究旨在通过横断面研究探讨 Sfrp5 与代谢综合征（MetS）之间的关系。
我们进行了一系列中国人群的横断面研究，包括 194 名对照参与者和 90 名 MetS 患者。通过 ELISA 测定循环 Sfrp5 浓度。评估循环 Sfrp5 水平与 MetS 成分之间的关系。
新诊断的 MetS 患者的循环 Sfrp5 明显低于对照组（49.1±17.2 与 61.6±23.2μg/L，P<.01）。循环 Sfrp5 与肥胖标志物（腰臀比、体重指数和游离脂肪酸，P<.001 或 P<.05）呈负相关。此外，Sfrp5 水平与空腹胰岛素、2 小时胰岛素、空腹血糖、葡萄糖负荷后 2 小时血糖、HbA1c 和胰岛素抵抗的稳态模型评估有关。此外，循环 Sfrp5 水平与血压、高密度脂蛋白胆固醇、甘油三酯和动脉粥样硬化指数密切相关。随着 MetS 成分数量的持续增加，循环 Sfrp5 浓度逐渐降低。受试者工作特征曲线分析显示，循环 Sfrp5 预测 MetS 的最佳截断值为 46.8μg/L（敏感性 70.1%，特异性 47.8%，AUC 0.66）。
我们得出结论，Sfrp5 可能是一种与人类 MetS 发病机制相关的脂肪因子。
