Kelly Conagh J, Chu Matthew, Untaru Rossana, Assadi-Khansari Bahador, Chen Dongqing, Croft Amanda J, Horowitz John D, Boyle Andrew J, Sverdlov Aaron L, Ngo Doan T M
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan 2308, Australia.
Hunter Medical Research Institute, New Lambton Heights 2305, Australia.
J Cardiovasc Dev Dis. 2023 Jun 28;10(7):274. doi: 10.3390/jcdd10070274.
Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels were measured via ELISA in 262 patients admitted to a cardiology unit. Plasma SFRP5 levels were significantly lower in patients with a history of heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF; = 0.001). In univariate analyses, SFRP5 levels were also significantly positively correlated with left ventricular ejection fraction (LVEF) (r = 0.52, < 0.001) and negatively correlated with E/E' (r = -0.30, < 0.001). Patients with HF, CAD, low LVEF, low triglycerides, high CRP, and high eGFR were associated with lower SFRP5 levels independent of age, BMI, or diabetes after multivariate analysis (overall model r = 0.729, SE = 0.638). Our results show that low plasma SFRP5 levels are independently associated with the presence of HF, CAD, and, importantly, impaired LV function. These results suggest a potential role of SFRP5 as a biomarker, as well as a mediator of cardiac dysfunction independent of obesity and metabolic regulation.
分泌型卷曲相关蛋白5（SFRP5）是一种新型抗炎脂肪因子，可能在心血管发育和疾病中发挥作用。然而，关于循环SFRP5是否可作为心脏功能的生物标志物，尚未有全面的研究。通过酶联免疫吸附测定法（ELISA）测量了262名入住心脏病科的患者的血浆SFRP5水平。有心力衰竭（HF）、冠状动脉疾病（CAD）和心房颤动（AF）病史的患者血浆SFRP5水平显著降低（P = 0.001）。在单变量分析中，SFRP5水平还与左心室射血分数（LVEF）显著正相关（r = 0.52，P < 0.001），与E/E' 负相关（r = -0.30，P < 0.001）。多变量分析后，独立于年龄、体重指数或糖尿病，HF、CAD、低LVEF、低甘油三酯、高CRP和高估算肾小球滤过率（eGFR）的患者与较低的SFRP5水平相关（总体模型r = 0.729，标准误 = 0.638）。我们的结果表明，低血浆SFRP5水平与HF、CAD的存在独立相关，重要的是，与左心室功能受损相关。这些结果表明SFRP5作为生物标志物的潜在作用，以及作为独立于肥胖和代谢调节的心脏功能障碍介质的作用。
