Creighton University, Omaha, Nebraska, USA.
Nutr Rev. 2014 Jan;72(1):48-54. doi: 10.1111/nure.12090. Epub 2013 Dec 13.
Presented here is a system to standardize clinical studies of nutrient effects, using nutrient-specific physiological criteria. These guidelines are based mainly on analysis of the typical sigmoid curve of biological response to nutrients and are intended for design, interpretation, and pooling of studies of nutrient effects. Five rules have been articulated for individual studies of nutrients, and six for systematic reviews and/or meta-analyses.
这里介绍了一种使用特定营养素的生理学标准来规范营养素影响的临床研究的系统。这些指南主要基于对营养素生物反应典型的 S 形曲线的分析，并旨在为营养素影响的研究设计、解释和汇总提供指导。已经为单个营养素研究制定了 5 条规则，为系统评价和/或荟萃分析制定了 6 条规则。
