Serrano K, Chen D, Hansen A L, Levin E, Turner T R, Kurach J D R, Acker J P, Devine D V
Canadian Blood Services, Centre for Innovation, Vancouver, BC, Canada; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Vox Sang. 2014 May;106(4):379-81. doi: 10.1111/vox.12112. Epub 2013 Dec 12.
While irradiation of red cell concentrates (RCC) prevents graft-versus-host disease in susceptible transfusion recipients, it also damages red blood cells (RBC). To understand the ability of irradiation regulations to prevent transfusion of inferior units, we irradiated 980 RCC in saline-adenine-glucose-mannitol (SAGM) using various combinations of pre-irradiation age and post-irradiation storage times, and measured hemolysis and extracellular potassium levels. We observed unacceptably high hemolysis (>0·8%) in some RCC and elevated extracellular potassium levels in all gamma-irradiated RCC. This suggests that more restrictive storage times should be considered for RCC in SAGM.
虽然对红细胞浓缩液（RCC）进行辐照可预防易感输血受者发生移植物抗宿主病，但它也会损害红细胞（RBC）。为了解辐照规则预防输注质量不佳单位血液的能力，我们使用辐照前保存时间和辐照后储存时间的各种组合，对980份保存在生理盐水 - 腺嘌呤 - 葡萄糖 - 甘露醇（SAGM）中的RCC进行辐照，并测量溶血和细胞外钾水平。我们观察到部分RCC出现了不可接受的高溶血率（>0·8%），并且所有经γ射线辐照的RCC细胞外钾水平均升高。这表明对于保存在SAGM中的RCC，应考虑更严格的储存时间。
