El Kenz H, Corazza F, Van Der Linden P, Chabab S, Vandenvelde C
Brugmann University Hospital Centre, Queen Fabiola University Children Hospital Blood Bank, Brussels, Belgium.
Transfus Apher Sci. 2013 Oct;49(2):249-53. doi: 10.1016/j.transci.2013.04.041. Epub 2013 May 25.
Prevention of transfusion-associated graft versus host disease (TA-GVHD) by gamma irradiation is known to induce increased K+ in supernatant of packed red blood cells (PRBCs) stored in CPDA-1 and SAGM conservative solutions. However, no data exist for PRBCs in AS-3 medium which is considered safe for neonatal transfusion. We evaluated haemolysis and K+ release from irradiated AS-3 PRBCs and compared our results with reported data for SAGM and CPDA-1 PRBCs. Our results indicate that irradiated PRBCs stored in AS-3 after more than 7 days post-irradiation should not be used in massive and/or rapidly infused transfusions in neonates and infants.
已知通过γ射线辐照预防输血相关移植物抗宿主病（TA-GVHD）会导致储存于CPDA-1和SAGM保存液中的浓缩红细胞（PRBCs）上清液中的钾离子（K+）增加。然而，对于被认为对新生儿输血安全的AS-3培养基中的PRBCs，尚无相关数据。我们评估了辐照后的AS-3 PRBCs的溶血情况和钾离子释放，并将我们的结果与已报道的SAGM和CPDA-1 PRBCs的数据进行了比较。我们的结果表明，辐照后7天以上储存在AS-3中的辐照PRBCs不应在新生儿和婴儿的大量和/或快速输注输血中使用。
