Pirogovsky Eva, Nicoll Diane R, Challener Dillon M, Breen Elizabeth, Gluhm Shea, Corey-Bloom Jody, Gilbert Paul E
Veterans Affairs, San Diego Health Care System, San Diego, California, USA; Department of Psychiatry, University of California San Diego, California, USA.
J Neuropsychol. 2015 Mar;9(1):77-86. doi: 10.1111/jnp.12036. Epub 2013 Dec 11.
Visual spatial memory was assessed using the Visual Spatial Learning Test (VSLT) in individuals with mild to moderate Huntington's disease (HD), pre-manifest gene carriers for HD, and demographically similar controls. The VSLT has been demonstrated to be a valid, normed measure of non-verbal memory involving minimal motoric responses. The VSLT assesses immediate and delayed memory for designs, positions of the designs, and design/position associations. The HD group was significantly impaired (p < .05) relative to both the control and Pre-HD groups on immediate and delayed memory for the designs, positions, and design/position associations. Although there were no differences between the Pre-HD and control groups on immediate or delayed memory for designs or positions, the Pre-HD group was significantly impaired (p < .05) relative to the control group on immediate and delayed memory for design/position associations. The results offer novel insight into a relatively unexamined memory deficit that may occur in gene carriers for HD prior to phenoconversion. The data indicate that the VSLT may be a useful measure of visuospatial memory during the premanifest and manifest stages of HD.
使用视觉空间学习测试（VSLT）对轻度至中度亨廷顿舞蹈病（HD）患者、HD症状前基因携带者以及人口统计学特征相似的对照组进行视觉空间记忆评估。VSLT已被证明是一种有效的、标准化的非语言记忆测量方法，涉及最少的运动反应。VSLT评估对图案、图案位置以及图案/位置关联的即时和延迟记忆。HD组在图案、位置以及图案/位置关联的即时和延迟记忆方面相对于对照组和症状前HD组均显著受损（p < 0.05）。虽然症状前HD组和对照组在图案或位置的即时或延迟记忆方面没有差异，但症状前HD组在图案/位置关联的即时和延迟记忆方面相对于对照组显著受损（p < 0.05）。这些结果为HD基因携带者在表型转换前可能出现的相对未被研究的记忆缺陷提供了新的见解。数据表明，VSLT可能是HD症状前和症状期视觉空间记忆的一种有用测量方法。
