Holden Heather M, Tierney Savanna M, Graves Lisa V, Beltran-Najera Ilex, Woods Steven Paul, Snell Chase M, Delis Dean C, Corey-Bloom Jody, Gilbert Paul E
San Diego State University-University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California.
Department of Psychology, University of Houston, Houston, Texas.
Cogn Behav Neurol. 2020 Mar;33(1):16-22. doi: 10.1097/WNN.0000000000000219.
Verbal memory impairment in individuals with Huntington disease (HD) is well-documented; however, the nature and extent of verbal memory impairment in individuals with premanifest HD (pre-HD) are less understood.
To evaluate verbal memory function in individuals with pre-HD by comparing their performance on the California Verbal Learning Test to that of individuals with a clinical diagnosis of HD and that of a demographically similar group of adults with no family history of, or genetic risk for, HD, thereby reducing possible complications of psychiatric difficulties commonly experienced by individuals who are at risk for HD but are gene negative.
Participant groups included 77 adults with a diagnosis of HD, 23 premanifest gene carriers for HD (pre-HD), and 54 demographically similar, healthy adults. The California Verbal Learning Test-Second Edition (CVLT-II) was used to evaluate the participants' immediate and delayed recall, recognition, learning characteristics, errors, and memory retention.
The pre-HD group performed significantly worse than the healthy group, yet significantly better than the HD group, on Short and Long Delay Recall (Free and Cued) and Recognition Discriminability. On Total Immediate Recall, Learning Slope, Semantic Clustering, and Intrusions, the pre-HD group performed similarly to the healthy group and significantly better than the HD group. None of the groups differed in their performance on Repetitions and a measure of retention.
Subtle memory deficits can be observed during the premanifest stage of HD with use of a subset of indices from the CVLT-II.
亨廷顿舞蹈症（HD）患者的言语记忆障碍已有充分记录；然而，症状前HD（pre-HD）患者言语记忆障碍的性质和程度尚鲜为人知。
通过比较症状前HD患者在加利福尼亚言语学习测试中的表现与临床诊断为HD的患者以及在人口统计学上相似但无HD家族史或遗传风险的成年人群体的表现，来评估症状前HD患者的言语记忆功能，从而减少有HD风险但基因检测为阴性的个体常见的精神疾病并发症。
参与者群体包括77名诊断为HD的成年人、23名HD症状前基因携带者（pre-HD）以及54名在人口统计学上相似的健康成年人。使用加利福尼亚言语学习测试第二版（CVLT-II）来评估参与者的即时和延迟回忆、识别、学习特征、错误以及记忆保持情况。
在短期和长期延迟回忆（自由和线索回忆）以及识别辨别方面，症状前HD组的表现明显比健康组差，但明显优于HD组。在即时总回忆、学习斜率、语义聚类和侵入方面，症状前HD组的表现与健康组相似，且明显优于HD组。在重复和一项记忆保持指标上，各组表现无差异。
使用CVLT-II的一部分指标，可在HD的症状前阶段观察到细微的记忆缺陷。
