Corey-Bloom Jody, Williams McKenna E, Beltran-Najera Ilex, Mustafa Andrea I, Snell Chase M, Castleton Jordan, Smith Haileigh, Wright Brenton, Gilbert Paul E
Department of Neurosciences University of California San Diego San Diego California USA.
Department of Psychology San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology San Diego California USA.
Mov Disord Clin Pract. 2020 Dec 28;8(1):100-105. doi: 10.1002/mdc3.13121. eCollection 2021 Jan.
Several studies have suggested that cognitive processing speed may be useful for assessing early cognitive change in premanifest Huntington's disease (HD); however, current measures lack the ability to control for the effects of motor dysfunction commonly found in HD. The Computerized Test of Information Processing (CTiP) is a rapidly administered computerized tool that allows for the examination of central cognitive processing speed by using motor-corrected scores to account for motor dysfunction.
To examine central cognitive processing speed as an early marker of HD onset using the CTiP.
The CTiP and other measures were administered to 102 HD gene carriers and 55 healthy adults (HA). Gene carriers included presymptomatic HD (pre-HD; n = 33), prodromal HD (pro-HD; ie, individuals close to disease onset; n = 23), and mild-moderate HD (HD; n = 46).
The HD group performed significantly slower than all other groups (HA, pre-HD, and pro-HD) on most subtests (s < .05). Moreover, the pro-HD group performed significantly slower than the HA group on both motor-corrected subtests (s < 0.05). Effect sizes associated with significant group differences between the pro-HD and HA groups on motor-corrected CTiP subtests ( = 0.73 and 0.84) were similar to effect sizes associated with group differences on the Symbol Digit Modalities Test ( = .82) and other traditional cognitive assessments (Montreal Cognitive Assessment, = .75; Mini-Mental State Examination, = .84).
The CTiP may be a useful marker of deficits in central cognitive processing speed in individuals close to manifest onset of HD.
多项研究表明，认知处理速度可能有助于评估临床前亨廷顿舞蹈病（HD）的早期认知变化；然而，目前的测量方法无法控制HD中常见的运动功能障碍的影响。计算机化信息处理测试（CTiP）是一种快速实施的计算机化工具，通过使用运动校正分数来考虑运动功能障碍，从而能够检查中枢认知处理速度。
使用CTiP检查中枢认知处理速度作为HD发病的早期标志物。
对102名HD基因携带者和55名健康成年人（HA）进行了CTiP及其他测量。基因携带者包括症状前HD（pre-HD；n = 33）、前驱HD（pro-HD；即接近疾病发作的个体；n = 23）和轻度至中度HD（HD；n = 46）。
在大多数子测试中，HD组的表现明显慢于所有其他组（HA、pre-HD和pro-HD）（s < .05）。此外，在两个运动校正子测试中，pro-HD组的表现明显慢于HA组（s < 0.05）。pro-HD组和HA组在运动校正CTiP子测试上显著组间差异的效应量（ = 0.73和0.84）与在符号数字模态测试（ = .82）和其他传统认知评估（蒙特利尔认知评估， = .75；简易精神状态检查表， = .84）上的组间差异效应量相似。
CTiP可能是接近HD明显发病个体中枢认知处理速度缺陷的有用标志物。
