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快速轴突运输过程中放射性分布的理论分析:沉积和周转的影响。

Theoretical analysis of radioactivity profiles during fast axonal transport: effects of deposition and turnover.

作者信息

Reed M C, Blum J J

出版信息

Cell Motil Cytoskeleton. 1986;6(6):620-7. doi: 10.1002/cm.970060610.

DOI:10.1002/cm.970060610
PMID:2433057
Abstract

In a preceding study [Blum, J.J., and Reed, M.C. (1985): Cell Motil. 5:507-527], factors responsible for the shape and velocity of the leading edge of the radiolabeled organelle profile were analyzed, but processes that might influence the shape of the plateau-like region behind the advancing wave were ignored. It is now shown that deposition of material from the fast transport system into membrane-associated structures, degradation of such deposited material and its return to the soma by the retrograde transport system, or leakage of radiolabeled material from the axon can account for the shape of the plateau. Furthermore, these processes are compatible with the maintenance of such structural inhomogeneities as the nodes of Ranvier.

摘要

在之前的一项研究中[布卢姆,J.J.,和里德,M.C.(1985年):《细胞运动》5:507 - 527],对负责放射性标记细胞器轮廓前沿形状和速度的因素进行了分析,但推进波后面类似高原区域形状的可能影响过程被忽略了。现在表明,物质从快速运输系统沉积到膜相关结构中、这种沉积物质的降解以及其通过逆行运输系统返回胞体,或者放射性标记物质从轴突泄漏,可以解释高原的形状。此外,这些过程与诸如郎飞结等结构不均匀性的维持是相容的。

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1
Theoretical analysis of radioactivity profiles during fast axonal transport: effects of deposition and turnover.快速轴突运输过程中放射性分布的理论分析:沉积和周转的影响。
Cell Motil Cytoskeleton. 1986;6(6):620-7. doi: 10.1002/cm.970060610.
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