Centre of Pharmaceutical Research-Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam.
Arch Pharm Res. 2015;38(5):677-82. doi: 10.1007/s12272-014-0432-3. Epub 2014 Jul 9.
A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.
从 Piper bavinum（胡椒科）的地上部分分离得到一种新的烯基酚，bavinol A（1），以及另外六种已知化合物（2-7）。通过包括 2D NMR 光谱在内的光谱分析确定了这些化合物的化学结构。从乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）抑制活性测定中评估了化合物 1-7 的抗阿尔茨海默病作用。Bavinol A（1）、ampelopsin（3）和violanthin（4）对 AChE 表现出抑制活性，IC50 值分别为 29.80、59.47 和 79.80μM。化合物 1 对 BChE 也表现出最强的抑制活性，IC50 值为 19.25μM。
