无溶剂条件下高效 PPA-SiO2 催化合成 β-烯胺酮。
Efficient PPA-SiO2-catalyzed synthesis of β-enaminones under solvent-free conditions.
机构信息
Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan.
出版信息
Molecules. 2013 Dec 10;18(12):15182-92. doi: 10.3390/molecules181215182.
Abstract
An efficient method has been developed for the synthesis of β-enaminones under solvent-free reaction conditions using PPA-SiO2 as catalyst. The reaction yields were good to excellent (up to 90%). This methodology affords high selectivity and good tolerance of a variety of different functional groups present on both aromatic and aliphatic amines. In addition, the methodology is environmentally benign and cost-effective due to absence of solvent and easy work-up.
摘要
已经开发出一种在无溶剂反应条件下使用 PPA-SiO2 作为催化剂合成β-烯胺酮的有效方法。反应收率良好至优秀（高达 90%）。该方法具有高选择性和对各种不同官能团的良好耐受性，这些官能团存在于芳香族和脂肪族胺中。此外，由于没有溶剂和易于处理，该方法具有环境友好和成本效益高的优点。
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