Wilson S P
Life Sci. 1987 Feb 16;40(7):623-8. doi: 10.1016/0024-3205(87)90262-1.
The neuropeptides substance P and vasoactive intestinal peptide (VIP), reported to exist in the splanchnic nerve terminals innervating the adrenal medulla, elevate the levels of enkephalin-containing peptides (ECPs) in cultured bovine adrenal medullary chromaffin cells. Cellular ECP stores were increased over 48 hr by 72 and 46 percent, respectively, following incubation with 5 microM VIP or 10 microM substance P, maximally effective concentrations. The results suggest that VIP and substance P may be trans-synaptic modulators of chromaffin cell ECP stores.
据报道，存在于支配肾上腺髓质的内脏神经末梢中的神经肽P物质和血管活性肠肽（VIP），可提高培养的牛肾上腺髓质嗜铬细胞中含脑啡肽肽（ECP）的水平。在与5 microM VIP或10 microM P物质（最大有效浓度）孵育后，细胞ECP储存量在48小时内分别增加了72%和46%。结果表明，VIP和P物质可能是嗜铬细胞ECP储存的跨突触调节剂。
