National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, China.
Nanoscale. 2014;6(3):1305-10. doi: 10.1039/c3nr05003c.
Tea polyphenol serves as an environmentally friendly ligand-exchange molecule to synthesize multifunctional metal-doped superparamagnetic iron oxide nanoparticles via a catechol-metal coordination interaction. The resultant particles not only exhibit excellent hydrophilicity and protein adsorption resistance, but also are applicable as magnetic resonance/fluorescent dual-imaging probes due to their high T₂ relaxivity, autofluorescence and large cellular uptake.
茶多酚作为一种环保的配体交换分子，通过儿茶酚-金属配位相互作用合成多功能金属掺杂超顺磁性氧化铁纳米粒子。所得粒子不仅表现出优异的亲水性和抗蛋白吸附性，而且由于其具有高 T₂弛豫率、自发荧光和较大的细胞摄取率，可用作磁共振/荧光双模式成像探针。
