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近红外活性多齿聚合物保护的氧化铁纳米颗粒作为 NIRF/PA/MR 三模态成像的多功能纳米探针。

Iron oxide nanoparticles protected by NIR-active multidentate-polymers as multifunctional nanoprobes for NIRF/PA/MR trimodal imaging.

机构信息

Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.

Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China.

出版信息

Nanoscale. 2016 Jan 14;8(2):775-9. doi: 10.1039/c5nr06660c.

DOI:10.1039/c5nr06660c
PMID:26658484
Abstract

We designed and synthesized new kinds of near-infrared catechol-based multidentate polymers which were intended to yield compact NIR-active iron oxide nanoparticles with excellent stability and biocompatibility. The resulted multifunctional nanoprobes showed great potential as multimodal contrast agents for NIRF/PA/MR trimodal imaging in vivo.

摘要

我们设计并合成了新型近红外邻苯二酚基多齿聚合物,旨在得到具有优异稳定性和生物相容性的紧凑近红外活性氧化铁纳米颗粒。所得多功能纳米探针有望成为用于体内近红外荧光/光声/磁共振三模态成像的多模态对比剂。

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