Dubreuil P, Morisset J
Regul Pept. 1986 Dec 1;16(1):51-67. doi: 10.1016/0167-0115(86)90194-1.
This study examines the effects of somatocrinin (GRF) and somatostatin antiserum (ASS), jointly and separately on gastric and duodenal growth. 24-day-old rats received twice daily SC injections of saline or GRF (4 and 20 micrograms X kg-1) for 14 days. ASS was given IP every 2 days. Alone, GRF increased gastric fundus weight concomitantly with DNA, RNA and protein contents producing hyperplasia and hypertrophy within this gland. Alone, ASS increased RNA and protein cellular concentrations. Joint ASS and GRF treatment stabilized the weight and protein content of the fundus, while reducing RNA contents as well as RNA and protein concentrations. GRF alone caused significant increments in duodenal weight and protein content suggesting cellular hypertrophy. Growth hormone, gastrin, cholecystokinin and secretin may be considered as putative mediators of these trophic effects.
本研究考察了生长激素释放因子（GRF）和生长抑素抗血清（ASS）单独及联合应用对胃和十二指肠生长的影响。24日龄大鼠每日皮下注射生理盐水或GRF（4和20微克/千克），共14天，每2天腹腔注射ASS。单独使用GRF可使胃底重量增加，同时伴有DNA、RNA和蛋白质含量增加，导致该腺体增生和肥大。单独使用ASS可增加RNA和蛋白质的细胞浓度。ASS和GRF联合治疗可稳定胃底重量和蛋白质含量，同时降低RNA含量以及RNA和蛋白质浓度。单独使用GRF可使十二指肠重量和蛋白质含量显著增加，提示细胞肥大。生长激素、胃泌素、胆囊收缩素和促胰液素可被视为这些营养作用的假定介质。
