Dubreuil P, Morisset J
Growth. 1986 Autumn;50(3):325-39.
Chronic treatment with rGRF for 14 days with or without a specific antibody against somatostatin-14 were performed on 24-day old male Sprague-Dawley rats. Serum GH concentrations were significantly increased at the time of sacrifice while growth was not affected. rGRF, possibly through its effect on GH release, stimulated lung and kidney weights, increasing water content of the latter. Muscle and testes remained insensitive to GRF while the heart showed signs of reduced growth. Liver growth responded positively to the combined rGRF and ASS treatments whereas the pancreas exhibited loss of weight; on both of these organs, GH may act directly. The increased weights of gastric fundus and duodenum may result from an indirect action of GH on serum levels of gastrointestinal hormones such as gastrin. The results of this study stress the specific response of each organ to increased GH serum levels and indicate that their respective growth control factors cannot be generalized.
对24日龄雄性斯普拉格-道利大鼠进行了为期14天的rGRF长期治疗，治疗过程中有无抗生长抑素-14的特异性抗体。处死时血清生长激素（GH）浓度显著升高，但生长未受影响。rGRF可能通过其对GH释放的作用，刺激了肺和肾的重量增加，增加了肾的含水量。肌肉和睾丸对GRF仍不敏感，而心脏显示出生长减缓的迹象。肝脏生长对rGRF和抗生长抑素-14联合治疗呈阳性反应，而胰腺则出现体重减轻；在这两个器官上，GH可能直接起作用。胃底和十二指肠重量增加可能是GH对胃肠激素如胃泌素血清水平的间接作用所致。本研究结果强调了各器官对血清GH水平升高的特异性反应，并表明它们各自的生长控制因素不能一概而论。
