Evolution. The hidden codes that shape protein evolution.
作者信息
Weatheritt Robert J, Babu M Madan
机构信息
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
出版信息
Science. 2013 Dec 13;342(6164):1325-6. doi: 10.1126/science.1248425.
Abstract
摘要
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本文引用的文献
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Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding.密码子最优性的进化保守性揭示了共翻译折叠的隐藏特征。
Nat Struct Mol Biol. 2013 Feb;20(2):237-43. doi: 10.1038/nsmb.2466. Epub 2012 Dec 23.
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Structural biology. Versatility from protein disorder.结构生物学。蛋白质无序带来的多功能性。
Science. 2012 Sep 21;337(6101):1460-1. doi: 10.1126/science.1228775.
3
Coding exons function as tissue-specific enhancers of nearby genes.外显子编码作为附近基因的组织特异性增强子发挥作用。
Genome Res. 2012 Jun;22(6):1059-68. doi: 10.1101/gr.133546.111. Epub 2012 Mar 22.
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Locating protein-coding sequences under selection for additional, overlapping functions in 29 mammalian genomes.在 29 种哺乳动物基因组中定位具有额外重叠功能的选择下的蛋白质编码序列。
Genome Res. 2011 Nov;21(11):1916-28. doi: 10.1101/gr.108753.110. Epub 2011 Oct 12.
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Understanding the contribution of synonymous mutations to human disease.理解同义突变对人类疾病的贡献。
Nat Rev Genet. 2011 Aug 31;12(10):683-91. doi: 10.1038/nrg3051.
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A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.IRGM 中的同义变体改变了 miR-196 的结合位点，导致克罗恩病中 IRGM 依赖性异噬作用失调。
Nat Genet. 2011 Mar;43(3):242-5. doi: 10.1038/ng.762. Epub 2011 Jan 30.
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Synonymous but not the same: the causes and consequences of codon bias.同义但不同：密码子偏好的原因和后果。
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Overlapping codes within protein-coding sequences.蛋白质编码序列中的重叠编码。
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Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence.为何蛋白质进化不仅仅关乎蛋白质功能：剪接、核小体与双编码序列。
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