[自我用药治疗家族性地中海热发作时的疼痛：旨在寻找疼痛管理的新方法]
[Self-medication to treat pain in attacks of familial Mediterranean fever: aiming to find a new approach to pain management].
作者信息
Giese A, Ornek A, Kurucay M, Kilic L, Şendur S N, Münker A, Puchstein C, Lainka E, Wittkowski H, Henning B F
机构信息
Medizinische Klinik I, St. Josef-Hospital Bochum, Ruhr-Universität Bochum, Gudrunstr. 56, 44791, Bochum, Deutschland,
出版信息
Schmerz. 2013 Dec;27(6):605-11. doi: 10.1007/s00482-013-1367-1.
BACKGROUND
Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by bouts of fever and serositis. Morbidity caused by bouts as well as self-medication were assessed among patients of Turkish ancestry living in Germany (D) or Turkey (T) in order to evaluate current analgetic concepts from a patient's perspective.
MATERIAL AND METHODS
D and T were asked about the 3 months preceding the interview.
RESULTS
A total of 40 D and 40 T were included; 35/40 D and 40/40 T were on colchicine. In the last 3 months, 61.3 % had ≥ 1 bout and suffered from peritonitis (87.8 %), fever (61.2 %), myalgia (45 %), pleuritis (42.8 %), arthralgia (36.7 %), and cephalgia (32.6 %). Of the patients, 65.3 % were bedridden during bouts, 61.2 % sought the attention of a physician, 53.1 % were unable to work or attend school, and 38.8 % were hospitalized. The following drugs were taken: NSAIDs (45.6 %), NSAIDs and paracetamol (42.6 %), and combinations of NSAIDs with other analgesics. NSAIDs (58.6 %) and paracetamol (20.7 %) were considered the most potent substances.
CONCLUSION
FMF inflicts substantial morbidity. Patients most commonly rely on NSAIDs and paracetamol to relieve symptoms of FMF bouts.
背景
家族性地中海热（FMF）是一种以发热和浆膜炎发作为特征的自身炎症性疾病。为了从患者角度评估当前的镇痛观念，对居住在德国（D）或土耳其（T）的土耳其裔患者发作引起的发病率以及自我用药情况进行了评估。
材料与方法
询问D组和T组患者在访谈前3个月的情况。
结果
共纳入40名D组患者和40名T组患者；40名D组患者中有35名、40名T组患者均服用秋水仙碱。在过去3个月中，61.3%的患者有≥1次发作，并患有腹膜炎（87.8%）、发热（61.2%）、肌痛（45%）、胸膜炎（42.8%）、关节痛（36.7%）和头痛（32.6%）。在发作期间，65.3%的患者卧床不起，61.2%的患者寻求医生帮助，53.1%的患者无法工作或上学，38.8%的患者住院治疗。患者服用了以下药物：非甾体抗炎药（NSAIDs，45.6%）、NSAIDs与对乙酰氨基酚（42.6%）以及NSAIDs与其他镇痛药的组合。NSAIDs（58.6%）和对乙酰氨基酚（20.7%）被认为是最有效的药物。
结论
FMF会导致严重的发病率。患者最常依靠NSAIDs和对乙酰氨基酚来缓解FMF发作的症状。
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