Central Patient Admission Unit/Emergency Department, Marienhospital Herne, Ruhr-University Bochum, Hölkeskampring 40, 44625 Herne, Germany.
Rheumatol Int. 2013 Jul;33(7):1713-9. doi: 10.1007/s00296-012-2622-y. Epub 2012 Dec 29.
We assessed quality of life (QOL) and disease activity in patients with Familial Mediterranean fever (FMF) of Turkish ancestry living in Germany or Turkey and conducted a correlation with FMF disease activity. 40 FMF patients in Turkey (TR), 40 FMF patients in Germany (G) and 40 healthy controls in Germany (C) were included. QOL was evaluated with the short form of the World Health Organisation Quality of Life scale (WHOQOL-BREF). FMF disease activity was examined with the Pras score. Mean age was TR 30.5 ± 10.6, G 35.2 ± 10.2, C 34.6 ± 10.7. Of the 120 participants, 77 were female. FMF patients in TR and G had a significantly decreased QOL physical health domain compared to controls (TR 59.7 ± 18.8, G 60.4 ± 19.4, C 76.5 ± 14.6). Turkish FMF patients had a lower QOL environment domain compared to controls (TR 62.3 ± 17.5, G 69.7 ± 16.5, C 72.3 ± 13.5). In the other QOL domains, no significant differences were found. The differences in QOL were robust to a regression analysis. No significant correlation between QOL and FMF disease activity was found. German FMF patients had longer duration of disease, younger age at onset and longer delay from disease onset to colchicine treatment. A total of 5 of 40 German FMF patients were not taking colchicine (TR:0). Erythrocyte sedimentation rate was lowest in TR with significant difference between TR and G as well as G and C (TR 13.2 ± 10.3, G 27.8 ± 19.4, C 16.3 ± 12.8 mm/h). C-reactive protein did not differ between TR and G. FMF has an important impact on QOL physical health domain. No correlation between FMF disease activity and the WHOQOL-BREF could be found.
我们评估了生活在德国或土耳其的土耳其裔家族性地中海热 (FMF) 患者的生活质量 (QOL) 和疾病活动，并与 FMF 疾病活动进行了相关性分析。纳入了土耳其的 40 名 FMF 患者 (TR)、德国的 40 名 FMF 患者 (G) 和德国的 40 名健康对照者 (C)。使用世界卫生组织生活质量量表 (WHOQOL-BREF) 的简表评估 QOL。用 Pras 评分评估 FMF 疾病活动。TR 的平均年龄为 30.5 ± 10.6，G 为 35.2 ± 10.2，C 为 34.6 ± 10.7。120 名参与者中，77 名女性。与对照组相比，TR 和 G 的 FMF 患者的 QOL 生理健康领域明显降低 (TR 59.7 ± 18.8，G 60.4 ± 19.4，C 76.5 ± 14.6)。与对照组相比，土耳其 FMF 患者的 QOL 环境领域较低 (TR 62.3 ± 17.5，G 69.7 ± 16.5，C 72.3 ± 13.5)。在其他 QOL 领域，未发现显著差异。QOL 差异在回归分析中是稳健的。未发现 QOL 与 FMF 疾病活动之间存在显著相关性。德国 FMF 患者的疾病持续时间较长，发病年龄较小，从发病到秋水仙碱治疗的时间间隔较长。在 40 名德国 FMF 患者中，共有 5 名未服用秋水仙碱 (TR：0)。TR 的红细胞沉降率最低，与 G 和 G 与 C 之间均有显著差异 (TR 13.2 ± 10.3，G 27.8 ± 19.4，C 16.3 ± 12.8 mm/h)。TR 和 G 之间的 C 反应蛋白无差异。FMF 对 QOL 生理健康领域有重要影响。未发现 FMF 疾病活动与 WHOQOL-BREF 之间存在相关性。
