Faure Céline, Gocho Kiyoko, Le Mer Yannick, Sahel José Alain, Paques Michel, Audo Isabelle
Fondation ophtalmologique Adolphe de Rothschild, 25 rue Manin, 75019, Paris, France,
Doc Ophthalmol. 2014 Feb;128(1):69-75. doi: 10.1007/s10633-013-9421-y. Epub 2013 Dec 13.
To report new findings in a case of ocular siderosis explored by high resolution angiography and adaptive optics (AO).
We report data on a 40-year-old man with an intraocular foreign body (IOFB) embedded in the sclera after hammering.
Nine months after this accident, the patient presented with full-field electroretinogram (FF-ERG) abnormalities. Subsequent IOFB extraction was performed. One month after the surgery, high resolution angiography showed for the first time small iron particles all over the inner retinal surface. Spreading of these deposits was followed by inflammatory prepapillary new vessels and venous retinal vasculatis, which spontaneously resolved within a few months. ERG responses became slightly electronegative at this time. Clearance of the iron particles was followed over a year with AO and ERG recording. AO revealed an arterial tropism with a decrease in the amount of particles overtime, which may be consistent with macrophagic activity.
High resolution angiography and AO are new tools, combined with electrophysiology, to better understand ocular siderosis pathophysiology.
报告通过高分辨率血管造影和自适应光学（AO）检查的一例眼铁质沉着症的新发现。
我们报告了一名40岁男性的数据，该患者在锤击后有一枚眼内异物（IOFB）嵌入巩膜。
此次事故九个月后，患者出现全视野视网膜电图（FF-ERG）异常。随后进行了眼内异物取出术。术后一个月，高分辨率血管造影首次显示整个视网膜内表面有小的铁颗粒。这些沉积物扩散后出现视乳头前炎性新生血管和视网膜静脉血管炎，数月内自行消退。此时ERG反应变为轻度电阴性。通过AO和ERG记录对铁颗粒的清除情况进行了一年的跟踪。AO显示铁颗粒数量随时间减少且有向动脉的趋向性，这可能与巨噬细胞活性一致。
高分辨率血管造影和AO是结合电生理学更好地理解眼铁质沉着症病理生理学的新工具。
