HIV 感染者中的抑郁症状与抗逆转录病毒治疗（ART）的启动。
Depressive symptoms and antiretroviral therapy (ART) initiation among HIV-infected Russian drinkers.
机构信息
Department of Psychology, Boston University, 648 Beacon Street, 4th Floor, Boston, MA, 02215, USA,
出版信息
AIDS Behav. 2014 Jun;18(6):1085-93. doi: 10.1007/s10461-013-0674-y.
The impact of depressive symptoms on ART initiation among Russian HIV-infected heavy drinkers enrolled in a secondary HIV prevention trial (HERMITAGE) was examined. We assessed 133 participants eligible for ART initiation (i.e., CD4 count <350 cells/μl) who were not on ART at baseline. Depressive symptom severity and ART use were measured at baseline, 6- and 12-months. Association between depressive symptoms and subsequent ART initiation was evaluated using GEE logistic regression adjusting for gender, past ART use, injection drug use and heavy drinking. Depressive symptom severity was not significantly associated with lower odds of initiating ART. Cognitive depression symptoms were not statistically significant (global p = 0.05); however, those with the highest level of severity had an AOR of 0.25 (95 % CI 0.09-0.71) for delayed ART initiation. Although the effect of depression severity was not significant, findings suggest a potential role of cognitive depression symptoms in decisions to initiate ART in this population.
我们考察了抑郁症状对参加二级艾滋病毒预防试验（HERMITAGE）的俄罗斯艾滋病毒感染者重度饮酒者开始接受抗逆转录病毒治疗（ART）的影响。我们评估了 133 名符合开始接受 ART 条件（即 CD4 计数<350 个细胞/μl）但在基线时未接受 ART 的参与者。在基线、6 个月和 12 个月时测量了抑郁症状严重程度和 ART 使用情况。使用广义估计方程逻辑回归调整性别、既往 ART 使用、注射吸毒和重度饮酒，评估抑郁症状与随后开始接受 ART 的相关性。抑郁症状严重程度与开始接受 ART 的可能性降低无关。认知抑郁症状无统计学意义（总体 p=0.05）；然而，严重程度最高的患者开始接受 ART 的比值比（AOR）为 0.25（95%CI 0.09-0.71）。尽管抑郁严重程度的影响不显著，但研究结果表明认知抑郁症状在该人群决定开始接受 ART 方面可能发挥作用。
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