Heuer H, Frenking B, Gülker H, Bender F
Z Kardiol. 1986 Nov;75(11):673-5.
A case report is given on a new method for treatment of drug-resistant slow ventricular tachycardias by automatic dynamic overdrive stimulation, using an implantable pacemaker system. In a 60-year-old patient with coronary heart disease and ventricular tachycardia refractory to drug therapy, an antitachycardia Medtronic pacemaker (type SP 0501) was implanted in October 1984 and used successfully in 65 attacks during 13 months. However, when trying to terminate the tachycardia by means of programmed stimulation, acceleration of the ectopic ventricular rate occurred at 8 occasions. The administration of the experimental antiarrhythmic drug diprafenone (Class Ic) resulted in a reduction of the ventricular frequency but not of the rate of attacks. Then the Vitatron Quintech DDD pacemaker was implanted, providing the chance of terminating the now reduced ventricular rate by the dynamic overdrive mode.
本文报告了一例使用植入式起搏器系统通过自动动态超速刺激治疗耐药性缓慢室性心动过速的新方法。一名60岁患有冠心病且药物治疗难治性室性心动过速的患者，于1984年10月植入了抗心动过速美敦力起搏器（型号SP 0501），并在13个月内成功用于65次发作。然而，在试图通过程控刺激终止心动过速时，有8次出现异位心室率加速。给予实验性抗心律失常药物双苯丙胺（Ic类）可降低心室频率，但不能减少发作次数。随后植入了Vitatron Quintech DDD起搏器，提供了通过动态超速模式终止现已降低的心室率的机会。
