Division of Pediatric Hematology/Oncology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Semin Thromb Hemost. 2014 Feb;40(1):41-8. doi: 10.1055/s-0033-1363166. Epub 2013 Dec 12.
Diagnosis of von Willebrand disease (VWD) merits consideration of personal and family history of bleeding symptoms along with confirmatory laboratory testing. As the latter yields quantifiable results, overreliance on a laboratory diagnosis may occur. However, existing tests for VWD contain potential sources for error. Both intrinsic and extrinsic factors affecting these assays can contribute to either falsely normal or falsely abnormal results. This article will discuss the present available assays as well as new developments in diagnostic testing. A clear understanding of the limitations of VWD testing is helpful for ensuring the correct diagnosis of affected patients.
诊断血管性血友病（VWD）需要考虑个人和家族的出血症状史，并结合确证性实验室检测。由于后者可提供定量结果，因此可能会过度依赖实验室诊断。然而，现有的 VWD 检测存在潜在的误差源。影响这些检测的内在和外在因素都可能导致结果异常或正常。本文将讨论目前可用的检测方法以及诊断检测的新进展。清楚了解 VWD 检测的局限性有助于确保对受影响患者的正确诊断。
