Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, P.R. China.
Adv Mater. 2014 Feb 12;26(6):931-6. doi: 10.1002/adma.201303360. Epub 2013 Dec 16.
Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core-shell-corona PIC nanoparticle (⊕) NP/Pt@PPC-DA as a next-generation delivery system. (⊕) NP/Pt@PPC-DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of (⊕) NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed.
作为新一代递药系统的理性设计 PIC 纳米颗粒：我们开发了一种核壳-冠 PIC 纳米颗粒（⊕）NP/Pt@PPC-DA 作为新一代递药系统。（⊕）NP/Pt@PPC-DA 表现出延长的循环和增强的肿瘤蓄积。随后，肿瘤 pH 值导致（⊕）NP/Pt 的释放，促进细胞摄取，随后快速细胞内顺铂释放。使用这种递药策略，成功抑制了小鼠异种移植模型中顺铂耐药肿瘤的生长。
