Ji Tianjiao, Kohane Daniel S
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nano Today. 2019 Oct;28. doi: 10.1016/j.nantod.2019.100765. Epub 2019 Aug 26.
Many diseases and conditions affect a relatively localized area of the body. They can be treated either by direct deposition of drug in the target area, or by giving the drug systemically. Here we review nanoparticle-based approaches to achieving both. We highlight advantages and disadvantages that nanoscale solutions have for locally administered therapies, with emphasis on the former. We discuss strategies to enable systemically delivered nanoparticles to deliver their payloads at specific locations in the body, including triggering (local and remote) and targeting.
许多疾病和病症会影响身体相对局部的区域。它们既可以通过将药物直接沉积在目标区域来治疗，也可以通过全身给药来治疗。在此，我们综述了基于纳米颗粒实现这两种治疗方式的方法。我们强调了纳米级解决方案在局部给药治疗方面的优缺点，重点是前者。我们还讨论了使全身递送的纳米颗粒能够在体内特定位置递送其 payload 的策略，包括触发（局部和远程）和靶向。
