Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA, 02155, USA.
Adv Mater. 2014 Feb;26(7):1105-10. doi: 10.1002/adma.201304244. Epub 2013 Dec 12.
A custom-made co-flow capillary device is used to synthesize monodisperse silk fibroin micro- and submicron-spheres with diameters tunable over a wide range of sizes. A model drug release is examined and control of degradation kinetics is obtained by changing sphere diameter.
采用定制的共流毛细管装置合成了具有广泛粒径可调范围的单分散丝素蛋白微球和亚微米球。通过改变球的直径,考察了模型药物的释放,并控制了降解动力学。