Herrlich P, Angel P, Rahmsdorf H J, Mallick U, Pöting A, Hieber L, Lücke-Huhle C, Schorpp M
Adv Enzyme Regul. 1986;25:485-504. doi: 10.1016/0065-2571(86)90030-0.
A number of carcinogenic and cocarcinogenic agents induce new gene products in mammalian cells including primary human skin fibroblasts. These have been defined by cDNA cloning techniques, by protein resolutions in 2D PAGE and by the detection of new enzymatic functions. The uniform and transient genetic reaction is tentatively called the genetic stress response.
许多致癌和促癌剂在包括原代人皮肤成纤维细胞在内的哺乳动物细胞中诱导新的基因产物。这些已通过cDNA克隆技术、二维聚丙烯酰胺凝胶电泳中的蛋白质解析以及新酶功能的检测得以界定。这种一致且短暂的基因反应被暂定称为遗传应激反应。
