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DNA损伤对培养的人成纤维细胞和角质形成细胞中主要组织相容性复合体I类蛋白合成的增强作用。

Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.

作者信息

Lambert M E, Ronai Z A, Weinstein I B, Garrels J I

机构信息

Cold Spring Harbor Laboratory, New York 11724.

出版信息

Mol Cell Biol. 1989 Feb;9(2):847-50. doi: 10.1128/mcb.9.2.847-850.1989.

DOI:10.1128/mcb.9.2.847-850.1989
PMID:2469006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362666/
Abstract

Exposure of primary human fibroblasts or simian virus 40-transformed human keratinocytes to several different classes of DNA damage, including UV light C (254 nm), resulted in a rapid increase in the expression of human major histocompatibility class I (MHC-I) proteins. MHC-I induction was also detected after exposure to low doses of the protein synthesis inhibitor cycloheximide, suggesting that MHC-I induction by DNA damage may be a component in a derepressible cellular SOS pathway.

摘要

将原代人成纤维细胞或猿猴病毒40转化的人角质形成细胞暴露于几种不同类型的DNA损伤，包括紫外线C（254纳米），会导致人类主要组织相容性复合体I类（MHC-I）蛋白的表达迅速增加。在暴露于低剂量的蛋白质合成抑制剂环己酰亚胺后也检测到MHC-I的诱导，这表明DNA损伤诱导MHC-I可能是可抑制的细胞SOS途径的一个组成部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6359/362666/2c9b71d6c18b/molcellb00050-0503-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6359/362666/9a63e514bcec/molcellb00050-0502-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6359/362666/2c9b71d6c18b/molcellb00050-0503-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6359/362666/9a63e514bcec/molcellb00050-0502-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6359/362666/2c9b71d6c18b/molcellb00050-0503-a.jpg

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本文引用的文献

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Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.大肠杆菌中的诱变作用及对脱氧核糖核酸损伤的诱导反应
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一个与trk癌基因激活相关的人类细胞序列是DNA损伤诱导型的。
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Ultraviolet light induces the expression of oncogenes in rat fibroblast and human keratinocyte cells.紫外线可诱导大鼠成纤维细胞和人角质形成细胞中癌基因的表达。
Oncogene. 1988 Feb;2(2):201-4.
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Cancer Res. 1987 Sep 1;47(17):4565-70.
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