Frigerio Alice, Bhama Prabhat K, Tan Oon T
Carolyn and Peter Lynch Center for Laser and Reconstructive Surgery, Harvard Medical School, Massachussets Eye and Ear Infirmary, Boston, Massachusetts.
Lasers Surg Med. 2013 Dec;45(10):633-8. doi: 10.1002/lsm.22176.
Outcomes analysis of laser treatment for port-wine stains (PWS) has been hampered by the lack of an objective measure of surface area and volume; moreover, treatment success is often gauged by clinician subjective assessment. Three-dimensional (3D) surface imaging has been applied in several medical disciplines to quantify surface changes, with promising results. We hypothesized that 3D surface imaging could be used to objectively measure changes in area and volume of PWS following laser treatment.
STUDY DESIGN/MATERIALS AND METHODS: We performed a retrospective review of consecutive patients with PWS treated over a 20-month time period. Area and volume of the lesions were measured using 3dMD photogrammetric software (3dMD; Atlanta, GA) before and after a series of sequential pulsed dye laser and/or alexandrite laser treatments.
Fifty-five patients with 59 PWS were included in the study. The initial average measured area was 45.6 cm(2) ; final average measured area decreased to 34.6 cm(2) (P < 0.001). The average volume change was 1.20 ml for all PWS included in the study and 1.90 ml for lesions that received at least five laser treatments within the study period.
Three-dimensional photography demonstrated area and volume changes in patients with PWS after laser treatments. Future studies to determine if statistically significant changes correlate with clinically appreciable changes are warranted.
由于缺乏对鲜红斑痣（PWS）表面积和体积的客观测量方法，鲜红斑痣激光治疗的疗效分析受到阻碍；此外，治疗效果往往由临床医生主观评估。三维（3D）表面成像已应用于多个医学学科以量化表面变化，结果令人鼓舞。我们假设3D表面成像可用于客观测量激光治疗后鲜红斑痣面积和体积的变化。
研究设计/材料与方法：我们对在20个月期间连续接受治疗的鲜红斑痣患者进行了回顾性研究。在一系列连续的脉冲染料激光和/或翠绿宝石激光治疗前后，使用3dMD摄影测量软件（3dMD；佐治亚州亚特兰大）测量病变的面积和体积。
55例患者的59处鲜红斑痣纳入研究。初始平均测量面积为45.6平方厘米；最终平均测量面积降至34.6平方厘米（P < 0.001）。研究中所有鲜红斑痣的平均体积变化为1.20毫升，在研究期间接受至少五次激光治疗的病变平均体积变化为1.90毫升。
三维摄影显示了激光治疗后鲜红斑痣患者的面积和体积变化。有必要进行进一步研究以确定统计学上的显著变化是否与临床上可察觉的变化相关。
