Kole Alakes Kumar, Roy Rammohan, Kole Dalia Chanda
Department of Medicine, North Bengal Medical College, Darjeeling, India.
Indian J Sex Transm Dis AIDS. 2013 Jul;34(2):107-12. doi: 10.4103/0253-7184.120542.
Musculoskeletal involvement in human immunodeficiency virus (HIV) infected patients are important disease manifestations, responsible for increased morbidity and also decreased quality of life.
To study the spectrum of different musculoskeletal involvement in HIV infected patients and its impact on quality of life.
Three hundred (n = 300) HIV-1 reactive patients were evaluated in respect to different musculoskeletal involvement including the quality of life from January 2010 to January 2011.
Male to female ratio was 11:1 with a mean age of 35 (±6.4) years and mean duration of the disease was 3 (±1.54) years. Majority of cases were truck drivers, motel workers, and jewelry workers. Musculoskeletal disorders were observed in a total of 190 cases (63.33%). The spectrum of musculoskeletal involvement was: Body ache in 140 (46.7%), arthralgia in 80 (26.7%), mechanical low back pain in 25 (8.3%), osteoporosis in 20 (6.7%), painful articular syndrome in 10 (3.3%), hypertrophic osteoarthropathy in two (0.7%), pyomyositis in two (0.7%), osteomyelitis in one (0.3%), and avascular bone necrosis in one patient (0.3%). Rheumatologic disorders associated were: Reactive arthritis in seven (2.3%), fibromyalgia in four (1.3%), septic arthritis in three (1%), acute gout in three (1%), spondyloarthropathy in two (0.7%), rheumatoid arthritis in two (0.7%), dermatomyositis in one (0.3%), and systemic lupus erythematosus (SLE) in one patient (0.3%). But HIV associated arthritis and diffuse infiltrative lymphocytosis syndrome (DILS) were not detected. Most of the patients had decreased quality of life.
Musculoskeletal involvement was common in HIV patients causing increased morbidity, so early detection and timely intervention is essential to improve quality of life.
肌肉骨骼系统受累是人类免疫缺陷病毒（HIV）感染患者重要的疾病表现，可导致发病率增加及生活质量下降。
研究HIV感染患者不同肌肉骨骼系统受累情况及其对生活质量的影响。
2010年1月至2011年1月期间，对300例HIV-1反应性患者进行了评估，内容包括不同的肌肉骨骼系统受累情况及生活质量。
男女比例为11:1，平均年龄35（±6.4）岁，平均病程3（±1.54）年。大多数病例为卡车司机、汽车旅馆工作人员和珠宝工人。共观察到190例（63.33%）肌肉骨骼疾病。肌肉骨骼系统受累情况如下：全身疼痛140例（46.7%）、关节痛80例（26.7%）、机械性下背痛25例（8.3%）、骨质疏松20例（6.7%）、疼痛性关节综合征10例（3.3%）、肥大性骨关节病2例（0.7%）、脓性肌炎2例（0.7%）、骨髓炎1例（0.3%）、1例患者出现缺血性骨坏死（0.3%）。相关的风湿性疾病有：反应性关节炎7例（2.3%）、纤维肌痛4例（1.3%）、化脓性关节炎3例（1%）、急性痛风3例（1%）、脊柱关节病2例（0.7%）、类风湿关节炎2例（0.7%）、皮肌炎1例（0.3%）、1例患者出现系统性红斑狼疮（SLE）（0.3%）。但未检测到HIV相关关节炎和弥漫性浸润性淋巴细胞增多综合征（DILS）。大多数患者生活质量下降。
肌肉骨骼系统受累在HIV患者中很常见，会导致发病率增加，因此早期发现和及时干预对于提高生活质量至关重要。
