1. Department of Cell Biology; University Medical Center Groningen, University of Groningen; Groningen, The Netherlands. ; 2. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); Department of Biochemistry and Molecular Biology; Peking University Health Science Center, Beijing 100191, China;
Int J Biol Sci. 2013 Dec 1;9(10):1121-33. doi: 10.7150/ijbs.6666. eCollection 2013.
Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.
自噬近年来受到了广泛关注。越来越多的蛋白质和信号通路被发现，它们以某种方式参与到自噬调控途径中。自噬的调控是复杂的，并且具有特定条件，在几种疾病中，自噬通量发生了改变。在这里，我们回顾了该领域最成熟的概念，以及报道的信号通路或成分，它们指导自噬机制。此外，我们将强调自噬通量在各种疾病中的变化，无论是作为疾病的原因还是作为应对细胞内环境改变的反应，以及自噬的调节如何可能被用作这些疾病的潜在治疗方法。
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