Majewski S, Tigalonowa M, Jabłónska S, Polakowski I, Janczura E
Arch Dermatol. 1987 Feb;123(2):221-5.
In former studies we have shown the increased angiogenic capability of peripheral blood mononuclear cells (MNCs) from patients with the active guttate type of psoriasis vulgaris. The present study tested the effects of serum factors from 67 patients with various forms of psoriasis vulgaris and from 32 healthy individuals on the angiogenic capability of normal human MNCs in an animal system. The angiogenesis-enhancing effect was most marked in the serum samples from patients with plaquelike and peripherally spreading lesions lasting for one to two months, and tended to disappear in patients with long-lasting and/or stationary lesions. Serum samples from patients with psoriasis were also capable of modulating the proliferation of normal human endothelial cells in vitro, and this modulation was correlated with the duration of relapse. The effects of psoriatic sera on normal human MNC function and on endothelial cell growth may be of importance for vascular proliferation in psoriasis.
在先前的研究中，我们已经表明，寻常型点滴状银屑病患者外周血单个核细胞（MNCs）的血管生成能力增强。本研究在动物系统中测试了67例各种类型寻常型银屑病患者和32例健康个体的血清因子对正常人MNCs血管生成能力的影响。血管生成增强作用在斑块状和边缘扩散性皮损持续1至2个月的患者血清样本中最为明显，而在皮损持续时间长和/或静止性皮损的患者中则趋于消失。银屑病患者的血清样本也能够在体外调节正常人内皮细胞的增殖，并且这种调节与复发持续时间相关。银屑病血清对正常人MNC功能和内皮细胞生长的影响可能对银屑病中的血管增殖具有重要意义。
