Majewski S, Wasik M, Jabłońska S, Tigałonowa M, Langner A
Department of Dermatology, Warsaw School of Medicine.
Arch Immunol Ther Exp (Warsz). 1989;37(3-4):465-70.
We studied the effects of products released from adhering neutrophils and serum factors from patients with psoriasis on angiogenic capability and natural cytotoxicity of normal human mononuclear cells. In active disseminated and guttate psoriasis, in which polymorphonuclear granulocytes were most adherent to the human vascular endothelium, supernatants from adhering neutrophils only slightly affected natural killer cell activity and angiogenic capability of normal human mononuclears. In peripherally spreading, plaque-like psoriasis, characterized by lower than in guttate psoriasis increase in granulocyte adherence, both neutrophil factors and patients sera markedly decreased NK cell activity and enhanced angiogenic capability of normal human peripheral blood mononuclear cells. The results suggest that neutrophil factors may affect some immune responses in patients with psoriasis.
我们研究了银屑病患者黏附的中性粒细胞释放的产物和血清因子对正常人单核细胞血管生成能力和自然细胞毒性的影响。在活动性播散性点滴状银屑病中，多形核粒细胞最易黏附于人体血管内皮，黏附的中性粒细胞的上清液仅轻微影响正常人单核细胞的自然杀伤细胞活性和血管生成能力。在边缘性扩展的斑块状银屑病中，其粒细胞黏附程度低于点滴状银屑病，中性粒细胞因子和患者血清均显著降低自然杀伤细胞活性，并增强正常人外周血单核细胞的血管生成能力。结果表明，中性粒细胞因子可能影响银屑病患者的某些免疫反应。
