Lee M L, To S S, Cooper A, Jones M, Schrieber L
Department of Rheumatology, Royal North Shore Hospital, St Leonards, NSW, Australia.
Clin Exp Immunol. 1993 Mar;91(3):346-50. doi: 10.1111/j.1365-2249.1993.tb05907.x.
Lymphocyte binding to cultured human umbilical vein endothelial cells was evaluated using a modified centrifugation binding assay in 15 patients with psoriasis and compared with three patients with atopic dermatitis, 11 patients with rheumatoid arthritis and 28 normal controls. Patients with psoriasis demonstrated 61% augmented lymphocyte binding compared with normal controls (P < 0.0001), which was not explained by differences in age and sex or an effect of psoriatic sera. In serial studies of six patients, this difference was found to be reversible with treatment and clinical improvement. Lymphocytes from patients with atopic dermatitis demonstrated decreased binding to endothelium (P < 0.005), while those from patients with rheumatoid arthritis were not different from normal controls. This is the first skin disease described in which augmented lymphocyte binding to endothelium occurs, and may represent a mechanism by which lymphocytes are targeted to psoriatic skin.
采用改良的离心结合试验，评估了15例银屑病患者的淋巴细胞与培养的人脐静脉内皮细胞的结合情况，并与3例特应性皮炎患者、11例类风湿关节炎患者及28例正常对照者进行了比较。银屑病患者的淋巴细胞结合较正常对照增强了61%（P < 0.0001），年龄、性别差异或银屑病血清的影响均无法解释这一现象。在对6例患者的系列研究中，发现这种差异在治疗及临床改善后是可逆的。特应性皮炎患者的淋巴细胞与内皮细胞的结合减少（P < 0.005），而类风湿关节炎患者的淋巴细胞与正常对照无差异。这是首次描述的淋巴细胞与内皮细胞结合增强的皮肤病，可能代表了淋巴细胞靶向银屑病皮肤的一种机制。
