Weenen T C, Jentink A, Pronker E S, Commandeur H R, Claassen E, Boirie Y, Singer P
Erasmus University Rotterdam, The Netherlands; Department of Virology, Erasmus Medical Center Rotterdam, The Netherlands.
Athena Institute, Vrije Universiteit Amsterdam, The Netherlands.
Clin Nutr. 2014 Oct;33(5):793-801. doi: 10.1016/j.clnu.2013.11.002. Epub 2013 Dec 15.
BACKGROUND & AIMS: A quantitative systematic identification and prioritization of unmet needs and research opportunities in relation to enteral nutrition was conducted by means of a tailor-made health research prioritization process.
The research objectives were reached by conducting qualitative interviews followed by quantitative questionnaires targeting enteral nutrition key opinion leaders (KOLs). (1) Define disease areas that deserve more research attention; (2) Rank importance of product characteristics of tube feeding (TF) and oral nutritional supplements (ONS); (3) Assess involvement of KOLs in enteral nutrition R&D process. KOLs ranked three product characteristics and three disease areas that deserve additional research attention. From these, overall priority scores were calculated by multiplying ranks for both product characteristics and disease areas.
17 qualitative interviews were conducted and 77 questionnaires (response rate 35%) were completed and returned. (1) Disease areas in ONS and TF with highest priorities are: ONS: general malnutrition & geriatrics, TF: intensive care. (2) TF product characteristics with highest priorities are: composition and clinical evidence from a KOL perspective; tolerance and ease of use from a patient perspective. ONS product characteristics with highest priorities are: composition, clinical evidence and taste from a KOL perspective; taste from a patient perspective. We find a high discrepancy between product characteristic prioritization from a KOL and patient perspective. (3) Although 62% of all KOLs give advice to enteral nutrition companies on patient needs, they under-influence the setting of research priorities by enteral nutrition companies.
This study provides a systematic approach to achieve research prioritization in enteral nutrition. In addition to providing new directions for enteral nutrition research and development, this study highlights the relevance of involving KOLs in the identification of research priorities as they have the ability to provide a balanced view of the unmet patient needs.
通过定制的健康研究优先级确定流程，对肠内营养方面未满足的需求和研究机会进行了定量系统识别和优先级排序。
通过对肠内营养关键意见领袖（KOL）进行定性访谈，随后开展定量问卷调查来实现研究目标。（1）确定值得更多研究关注的疾病领域；（2）对管饲（TF）和口服营养补充剂（ONS）的产品特性重要性进行排序；（3）评估KOL在肠内营养研发过程中的参与情况。KOL对三个值得额外研究关注的产品特性和三个疾病领域进行了排序。据此，通过将产品特性和疾病领域的排名相乘来计算总体优先级得分。
进行了17次定性访谈，完成并返回了77份问卷（回复率35%）。（1）ONS和TF中优先级最高的疾病领域分别为：ONS：一般营养不良和老年病，TF：重症监护。（2）TF优先级最高的产品特性为：从KOL角度看成分和临床证据；从患者角度看耐受性和易用性。ONS优先级最高的产品特性为：从KOL角度看成分、临床证据和口味；从患者角度看口味。我们发现从KOL和患者角度对产品特性的优先级排序存在很大差异。（3）尽管所有KOL中有62%就患者需求向肠内营养公司提供建议，但他们对肠内营养公司研究优先级的设定影响不足。
本研究提供了一种在肠内营养中实现研究优先级排序的系统方法。除了为肠内营养研发提供新方向外，本研究还强调了让KOL参与研究优先级识别的相关性，因为他们有能力对未满足的患者需求提供全面的看法。
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