Dib B
Eur J Pharmacol. 1987 Jan 13;133(2):147-53. doi: 10.1016/0014-2999(87)90145-2.
A climatic chamber at an ambient temperature (Ta) of 20 and 30 degrees C was used to examine the effect on thermoregulation in the rat of substance P (SP) injected into the lumbar subarachnoid space via a chronic indwelling catheter. In the first series of experiments, the rats had no access to the lever in the climatic chamber. At Ta of 20 degrees C, intrathecal (IT) injections of SP or saline had no effect on body temperature. In the second series of experiments, the rats had access to the lever which actuated a fan that drew cool outside air into the chamber. At Ta 20 and 30 degrees C, IT injection of SP stimulated the activation of bar-pressing to obtain air for cooling. This behaviour was more evident when Ta was 30 degrees C. Under similar conditions, IT injection of saline did not activate bar-pressing. These findings suggest that spinal cord SP receptors may be involved in the control of body temperature.
在环境温度（Ta）为20摄氏度和30摄氏度的气候箱中，通过慢性留置导管向大鼠腰蛛网膜下腔注射P物质（SP），以研究其对大鼠体温调节的影响。在第一组实验中，大鼠无法接触气候箱中的杠杆。在20摄氏度的Ta条件下，鞘内（IT）注射SP或生理盐水对体温没有影响。在第二组实验中，大鼠可以接触到控制风扇的杠杆，该风扇将凉爽的外部空气吸入箱内。在20摄氏度和30摄氏度的Ta条件下，IT注射SP刺激了按压杠杆以获取冷空气的行为。当Ta为30摄氏度时，这种行为更为明显。在类似条件下，IT注射生理盐水不会激活按压杠杆的行为。这些发现表明脊髓SP受体可能参与体温控制。
